Tachykinin Antagonists with Cyclic Structures
During the last years, huge efforts have been made to upgrade the available tachykinin antagonists. We and several groups have done design studies with purely synthetic permutation series [1,2], others have attempted mathematical predictions based on various physicochemical considerations  but in no case antagonists with pA2-values above 8 were obtained or which satisfied all pharmacological criteria of selectivity and specificity.
KeywordsAromatic Amino Acid Adipic Acid Linear Precursor Bridgehead Position Kinin Antagonist
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