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Tachykinin Antagonists with Cyclic Structures

  • E. Escher
  • P. D’Orléans-Juste
  • S. Dion
  • D. Regoli
Conference paper

Abstract

During the last years, huge efforts have been made to upgrade the available tachykinin antagonists. We and several groups have done design studies with purely synthetic permutation series [1,2], others have attempted mathematical predictions based on various physicochemical considerations [3] but in no case antagonists with pA2-values above 8 were obtained or which satisfied all pharmacological criteria of selectivity and specificity.

Keywords

Aromatic Amino Acid Adipic Acid Linear Precursor Bridgehead Position Kinin Antagonist 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • E. Escher
    • 1
  • P. D’Orléans-Juste
    • 1
  • S. Dion
    • 1
  • D. Regoli
    • 1
  1. 1.Department of Pharmacology, Faculty of MedicineUniversity of SherbrookeSherbrookeCanada

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