Multiple Neurokinin Receptors in the Rat Lower Urinary Tract
In recent years huge evidence has accumulated indicating that neuropeptides are widely distributed in the lower urinary tract of various animal species(l). The aim of this study was to determine the relative ability of neurokinins (subs tance P, SP; neurokinin A, NKA; neurokinin B, NKB) and tachykinins (kassinin, KASS; eledoisin, ELE; physalaemin, PHYS) to activate motility and produce plasma extravasation in the rat lower urinary tract. The effects of neurokinins (NKs) and tachykinins (TKs) were compared to those of capsaicin, a drug known to stimulate neuropeptide release from primary afferent fibers (2).
KeywordsCalcitonin Gene Related Peptide Evans Blue Rhythmic Contraction Plasma Extravasation Primary Afferent Fiber
Unable to display preview. Download preview PDF.
- 1.Maggi CA, Meli A (1986) The role of neuropeptides in the regulation of the micturition reflex. J. Autonom Pharmacol in pressGoogle Scholar
- 4.Maggi CA, Santicioli P, Giuliani S, Regoli D, Meli A (1986) Activation of micturition rflex by substance P and substance K: indirect evidence of the existence of multiple tachykinin receptors in the rat urinary bladder. J Pharmacol Exp Ther in pressGoogle Scholar
- 7.Regoli D, D’Orleans-Juste P, Drapeau G, Dion S, Escher E (1985) Pharmacological characterization of substance P antagonists In: Hakanson R, Sundler F (eds) Tachykinin antagonists, Elsevier, Netherlands pp 277–287Google Scholar