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Multiple Neurokinin Receptors in the Rat Lower Urinary Tract

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Substance P and Neurokinins

Abstract

In recent years huge evidence has accumulated indicating that neuropeptides are widely distributed in the lower urinary tract of various animal species(l). The aim of this study was to determine the relative ability of neurokinins (subs tance P, SP; neurokinin A, NKA; neurokinin B, NKB) and tachykinins (kassinin, KASS; eledoisin, ELE; physalaemin, PHYS) to activate motility and produce plasma extravasation in the rat lower urinary tract. The effects of neurokinins (NKs) and tachykinins (TKs) were compared to those of capsaicin, a drug known to stimulate neuropeptide release from primary afferent fibers (2).

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References

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Author information

Authors and Affiliations

  1. Pharmacology Department, A. Menarini Pharmaceuticals, Via Sette Santi, 3, Florence, Italy

    C. A. Maggi, P. Santicioli, S. Giuliani, M. Parlani & A. Meli

  2. C.R.F, Rome, Italy

    L. Abelli & M. Furio

Authors
  1. C. A. Maggi
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  2. P. Santicioli
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  3. L. Abelli
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  4. S. Giuliani
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  5. M. Furio
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  6. M. Parlani
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  7. A. Meli
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Editor information

Editors and Affiliations

  1. Department of Physiology, McGill University, Montreal, Quebec, H3G 1Y6, Canada

    James L. Henry Ph.D.

  2. Department of Physiology, University of Montreal, C.P. 6208, Montreal, Quebec, H3C 3T8, Canada

    Rejean Couture Ph.D.

  3. Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, H3G 1Y6, Canada

    A. Claudio Cuello M.D.

  4. MRC Group in Molecular Endocrinology, Centre Hospitalier de L’Universite, Laval, Quebec, G1V 4G2, Canada

    Georges Pelletier Ph.D.

  5. Douglas Hospital Research Centre and Department of Psychiatry, McGill University, Verdun, Quebec, H4H 1R3, Canada

    Remi Quirion Ph.D.

  6. Department of Pharmacology, Medical School, University of Sherbrooke, Sherbrooke, Quebec, J1H 5N4, Canada

    Domenico Regoli M.D.

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© 1987 Springer-Verlag New York Inc.

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Maggi, C.A. et al. (1987). Multiple Neurokinin Receptors in the Rat Lower Urinary Tract. In: Henry, J.L., Couture, R., Cuello, A.C., Pelletier, G., Quirion, R., Regoli, D. (eds) Substance P and Neurokinins. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4672-5_37

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  • DOI: https://doi.org/10.1007/978-1-4612-4672-5_37

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-9109-1

  • Online ISBN: 978-1-4612-4672-5

  • eBook Packages: Springer Book Archive

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