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Substance P and Neurokinins pp 108–110Cite as

Substance-P-Induced Desensitization in Canine Cephalic Arteries is not Mimicked by Substance K, Physalaemin, or Kassinin

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Abstract

The responses of cephalic blood vessels to the addition of substance P or substance K were compared in canine cephalic vascular tissues. Both tachykinins relaxed precontracted segments of common carotid and basilar arteries. The addition of SP caused significant homologous desensitization but not desensitization to the subsequent addition of bradykinin, calcitonin generelated peptide or sodium nitroprusside. Comparatively little or no homologous desensitization followed the addition of SP- [4–11], SK or physa1aemin.,SP pretreatment but not pretreatment with SK kassinin physa1aemin or e1edoisin attenuated the vasodi1ating response to substance K. SK did not however, induce tachyphylaxis to the subsequent addition of substance P. Taken together these data suggest that the unique N-termina1 peptide sequence of SP mediates the tachykinin-induced desensitization within canine vascular tissues. The extent to which this mechanism accounts for tachykinin-induced desensitization in other systems remains to be determined

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References

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Author information

Authors and Affiliations

  1. Depts of Neurosurgery and Neurology, Massahusetts General Hospital, Boston, MA, 02114, USA

    M. A. Moskowitz, C. Kuo, S. E. Leeman & M. Jessen

  2. Dept. of Physiology, University of Massachusetts Medical Center, Worcester, MA, USA

    M. A. Moskowitz, C. Kuo, S. E. Leeman & M. Jessen

Authors
  1. M. A. Moskowitz
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  2. C. Kuo
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  3. S. E. Leeman
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  4. M. Jessen
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Editor information

Editors and Affiliations

  1. Department of Physiology, McGill University, Montreal, Quebec, H3G 1Y6, Canada

    James L. Henry Ph.D.

  2. Department of Physiology, University of Montreal, C.P. 6208, Montreal, Quebec, H3C 3T8, Canada

    Rejean Couture Ph.D.

  3. Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, H3G 1Y6, Canada

    A. Claudio Cuello M.D.

  4. MRC Group in Molecular Endocrinology, Centre Hospitalier de L’Universite, Laval, Quebec, G1V 4G2, Canada

    Georges Pelletier Ph.D.

  5. Douglas Hospital Research Centre and Department of Psychiatry, McGill University, Verdun, Quebec, H4H 1R3, Canada

    Remi Quirion Ph.D.

  6. Department of Pharmacology, Medical School, University of Sherbrooke, Sherbrooke, Quebec, J1H 5N4, Canada

    Domenico Regoli M.D.

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© 1987 Springer-Verlag New York Inc.

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Moskowitz, M.A., Kuo, C., Leeman, S.E., Jessen, M. (1987). Substance-P-Induced Desensitization in Canine Cephalic Arteries is not Mimicked by Substance K, Physalaemin, or Kassinin. In: Henry, J.L., Couture, R., Cuello, A.C., Pelletier, G., Quirion, R., Regoli, D. (eds) Substance P and Neurokinins. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4672-5_36

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  • DOI: https://doi.org/10.1007/978-1-4612-4672-5_36

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-9109-1

  • Online ISBN: 978-1-4612-4672-5

  • eBook Packages: Springer Book Archive

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