Tachykinin P-type Binding Sites in Dog Kidney

  • R. J. Summers
  • J. A. Stephenson
  • E. Burcher
Conference paper


Substance P (SP) has potent natriuretic and diuretic properties, increases renal blood flow and decreases renin release in dog kidney [1–3]. It has been suggested that some of the effects of SP in kidney result from bradykinin release [3] or increases in renal cAMP levels [4]. More recently it has been shown that SP mediated vasodilatation in renal arteries is endothelium-dependent [5] and is probably mediated by release of endothelium-derived relaxing factor (EDRF) [5,6]. In this study autoradiographic techniques with [ 125I] Bolton-Hunter substance P (BHSP) have been used to determine the localization of BHSP binding sites in dog kidney sections.


Renal Artery Renal Blood Flow Renin Release Coated Coverslip Intimal Surface 
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Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • R. J. Summers
    • 1
  • J. A. Stephenson
    • 1
  • E. Burcher
    • 2
  1. 1.Department of PharmacologyUniversity of MelbourneAustralia
  2. 2.Department of Biological and Health SciencesDeakin UniversityAustralia

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