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Multiple Tachykinin Binding Sites in Hamster, Guinea-Pig and Rat Bladder

  • E. Burcher
  • S. H. Buck
Conference paper

Abstract

The tachykinin peptides are potent contractile agents in mammalian urinary bladder. This action appears to be mediated predominant1y by a direct action on smooth muscle since it is generally not altered by atropine, guanethidine, mepyramine or indomethacin [1,2]. As in other smooth muscle preparations, it has been suggested that there is more than one type of tachykinin receptor in mammalian bladder since PHYS is more potent than ELE or SP in rat, guinea-pig, and cat bladder whereas in hamster, mouse, dog, pig, monkey, and human bladder HE and KASS are substantially more potent than SP or PHYS. In view of the recent identification of three distinct types of tachykinin binding sites in the CNS and periphery that may be receptors for each of the three mammalian tachykinins, SP, SK, and NK, we have examined tachykinin binding sites in hamster, rat, and guinea-pig urinary bladder [see 3,4,5].

Keywords

Contractile Effect Tachykinin Receptor Smooth Muscle Preparation Contractile Agent Kinin Binding 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Sjogren, C, Andersson, KE, Husted, S (1982) Contractile effects of some polypeptides on the isolated urinary bladder of guinea pig, rabbit, and rat. Acta Pharmacol. Toxicol. 50: 175–184.CrossRefGoogle Scholar
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    Watson, SP (1984) Are the proposed substance P receptor subtypes, substance P receptors Life Sci. 25: 797–808.CrossRefGoogle Scholar
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    Quirion, R (1985) Multiple tachyki ni n receptors. Trends Neurosci. 8: 183–185.CrossRefGoogle Scholar
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    Buck, SH, Burcher, E (1986) The tachykinins: a family of peptides with a brood of ‘receptors’. Trends Pharmacol. Sci. 7: 65–68.CrossRefGoogle Scholar
  5. 5.
    Burcher, E, Buck, SH, Lovenberg, W, O’Donohue, TL (1986) Characterization and autoradi ographic localization of multiple tachykinin binding sites in gastrointestinal tract and bladder. J. Pharmacol. Exp. Ther. 236: 819–831.PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • E. Burcher
    • 1
  • S. H. Buck
    • 2
  1. 1.Division of Biological & Health SciencesDeakin UniversityAustralia
  2. 2.Division of Biochemical SciencesMerrell Dow Research InstituteCincinnatiUSA

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