Interaction of Analgesic Capsaicin Analogs with Substance P Receptors
NE-19550 is an orally active capsaicin analog whose analgesic and anti-inflammatory actions were recently described. Recent studies have shown that the analgesic properties of this compound are not opioid in character, despite its good efficacy in the rodent hot-plate and tail flick assays for antinociception. Further, it has been established that the anti-inflammatory analgesic activity displayed by NE-19550 in the carrageenan rat paw edema assay and other tests does not involve NSAID-like inhibition of prostanoid synthesis.
KeywordsButyl Phthalate Capsaicin Analogue Dinonyl Phthalate Tail Flick Assay Culture Roller Bottle
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