Interaction of Analgesic Capsaicin Analogs with Substance P Receptors

  • D. G. Payan
  • L. M. Brand
Conference paper


NE-19550 is an orally active capsaicin analog whose analgesic and anti-inflammatory actions were recently described[1]. Recent studies have shown that the analgesic properties of this compound are not opioid in character, despite its good efficacy in the rodent hot-plate and tail flick assays for antinociception[2]. Further, it has been established that the anti-inflammatory analgesic activity displayed by NE-19550 in the carrageenan rat paw edema assay and other tests does not involve NSAID-like inhibition of prostanoid synthesis[3].


Butyl Phthalate Capsaicin Analogue Dinonyl Phthalate Tail Flick Assay Culture Roller Bottle 
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Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • D. G. Payan
    • 1
  • L. M. Brand
    • 2
  1. 1.Dept. of MedicineUniv.of California Med. CtrSan FranciscoUSA
  2. 2.The Procter & Gamble CoCincinnatiUSA

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