Advertisement

Interaction of Analgesic Capsaicin Analogs with Substance P Receptors

  • D. G. Payan
  • L. M. Brand
Conference paper

Abstract

NE-19550 is an orally active capsaicin analog whose analgesic and anti-inflammatory actions were recently described[1]. Recent studies have shown that the analgesic properties of this compound are not opioid in character, despite its good efficacy in the rodent hot-plate and tail flick assays for antinociception[2]. Further, it has been established that the anti-inflammatory analgesic activity displayed by NE-19550 in the carrageenan rat paw edema assay and other tests does not involve NSAID-like inhibition of prostanoid synthesis[3].

Keywords

Butyl Phthalate Capsaicin Analogue Dinonyl Phthalate Tail Flick Assay Culture Roller Bottle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Reference

  1. 1.
    LaHann TR, Buckwalter BL (1985) Compositions and Methods Useful for Producing Analgesia. U.S. Patent 4, 493, 848Google Scholar
  2. 2.
    Berman EF, Schwen RJ, LaHann TR, Gardnor JH, Janusz JM, Buckwalter BL, Brand LM (1986) NE-19550, novel nonnarcotic analgesic agent. Fed Proc 45:665Google Scholar
  3. 3.
    Brand LM, Skare KL, Loomans ME, Skoglund ML, Tai HH, Chiabrando C, Fanelli R (1986) NE-19550, an anti-inflammatory analgesic with a novel mechanism. Fed Proc 45:334Google Scholar
  4. 4.
    Lembeck F, Donnerer J (1981) Time course of capsaicin-induced functional impairment compared with neuronal Substance P content. Naunyn-Schmiedeberg’s Arch Pharmacol 316:240–243CrossRefGoogle Scholar
  5. 5.
    Lembeck F, Folkers K, Donnerer J (1981) Analgesic effect of antagonists of Substance P. Biochem Biophys Res Comm 103:1318–1321PubMedCrossRefGoogle Scholar
  6. 6.
    Rosell S, Olgart L, Gazolius B, Panopoulous P, Folkers K, Hovig J (1981) Inhibition of antidronic and substance Pinduced vasodilation by a substance Pantagonist. Acta Physiol Scand 111:381–385.PubMedCrossRefGoogle Scholar
  7. 7.
    Payan DG, Brewster DR, Goetzl EJ (1984) Human lymphoblast receptors for substance P. J Immunol 133:3260–3265PubMedGoogle Scholar
  8. 8.
    Payan DG, Brewster DR, MissirianBastian A, Goetzl EJ (1984) Human T lymphocyte binding of substance P. J Clin Invest 74:1532–1539PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • D. G. Payan
    • 1
  • L. M. Brand
    • 2
  1. 1.Dept. of MedicineUniv.of California Med. CtrSan FranciscoUSA
  2. 2.The Procter & Gamble CoCincinnatiUSA

Personalised recommendations