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Effects of Substance P on the Binding of Ligands to Nicotinic Acetylcholine Receptors on Torpedo Electroplaque Membranes

  • S. M. Simasko
  • G. A. Weiland
Conference paper

Abstract

Substance P has been shown to noncompetitively inhibit nicotinic acetylcholine receptor (nAChR) responses in a number of experimental systems. These include among others, spinal Renshaw cells [1,2], adrenal chromaffin cells [3,4], a neuronal cell line (PCl2) [5,6], and a muscle-like cell line (BC3HI) [6]. The effect of substance P has been shown to be specific for the nAChR; substance P fails to alter excitation responses by glutamate, aspartate, or muscarinic agoinsts [1,2], and fails to block secretion induced by depolarization by high potassium or veratridine [3,4]. It has recently been shown that the site through which substance P exerts this effect is probably different from sites previously described for the peptide [6].

Keywords

Nicotinic Acetylcholine Receptor Neuronal Cell Line Adrenal Chromaffin Cell Renshaw Cell Agonist Binding Site 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • S. M. Simasko
    • 1
  • G. A. Weiland
    • 1
  1. 1.Dept. of PharmacologyNYSCVM, Cornell UIthacaUSA

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