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Toward the Bioactive Conformation of Tachykinins?

  • G. Chassaing
  • O. Convert
  • S. Lavielle
  • O. Ploux
Conference paper

Abstract

The knowledge of binding-site topography is an essential step in the understanding of a receptor-substrate recognition process. However, the direct study of such complex is presently limited in application. Nevertheless, a binding site can be considered as being the imprint of the three-dimensional structure of its substrate. Taking into account the associative properties of the substance P to phospholipids and the aggregation behaviour of the tachykinins, we propose a two-step binding mechanism of these peptides to their receptors. First, the substrate binds to the phospholipids component of the membrane. This is followed by a two-dimensional diffusion of the tachykinins and of its receptor on the surface of the membrane, resulting in the formation of the substrate-receptor complex.

Keywords

Exchange Rate Helical Conformation Slow Exchange Associative Property Bioactive Conformation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • G. Chassaing
    • 1
  • O. Convert
    • 2
  • S. Lavielle
    • 1
  • O. Ploux
    • 1
  1. 1.Laboratoire de Chimi Organique BiologiqueCNRS UA 493 Université P. et MParisFrance
  2. 2.Laboratoire de Chimie Organique StructuraleCNRS UA 455 Université P. et MParisFrance

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