Abstract
In recent years. substance P and related tachykinins have been shown to stimulate inositol phospholipid hydrolysis in a variety of tissues, including rat salivary gland [1], guinea pig ileum longitudinal muscle and rat hypothalamus [2]. In these tissues substance P, eledoisin and substance P methyl ester possess similar nanomolar potencies at inducing this response suggesting that inositol phospholipid breakdown is associated with SP-P receptor activation [2]. However. in slices of rat ileum longitudinal muscle. eledoisin is considerably more potent than substance P at stimulating inositol phospholipid hydrolysis suggesting that in some tissues this response may be mediated by a SP-E receptor [3]. In order to investigate further the association of SP-E receptors with inositol phospholipid breakdown, we examined tachykinin-induced inositol-l-phosphate production in slices of hamster urinary bladder, a tissue whose contractile response exhibits a typical SP-E receptor profile [4].
Keywords
- Krebs Solution
- Inositol Phospholipid
- Tachykinin Receptor
- Stimulate Concentration
- Ammonium Formate Solution
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References
Hanley M R. Lee C M. Jones L M and Michell R H. (1980). Similar effects of substance P and related peptides on salivation and on phosphatidylinositol turnover in rat salivary glands. Mol Pharmac. 18. 8–83.
Watson S P. and Downes C P. (1983). Substance P induced hydrolysis of inositol phospholipids in guinea pig ileum and rat hypothalamus. Eur J Pharmac 93. 245–253.
Watson SP. (1984). The action of substance P on contraction. inositol phospholipids and adenylate cyclase in rat small intestine. Biochem Pharmac 12. 3733–3737.
Watson S P. Sandberg B E B. Hanley M R and Iversen L L. (1983). Tissue selectivity of substance P alkyl esters suggesting multiple receptors. Eur J Pharmac 87. 77–84.
Berridge M J. Downes C P and Hanley M R. (1982). Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands. Biochem J. 206. 587–595.
Berrridge M J. Dawson R M C. Downes C P. Heslop J P and Irvine R F. (1983) Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides. Biochem J 212. 473–482.
Hallcher L M. and Sherman W R. (1980). The effects of lithium ion and other agents on the activity of myo-inositol-l-phosphatase from bovine brain. J BioI Chem. 255. 10897–10901.
Piercey M F. Dorby-Schreur P J K. Masiques N and Schroeder L. (1985). Stereospecificity of SP1 and SP2 substance Preceptors. Life Sci. 36. 777–780.
Piercey M F. Dobry F. Einspahr L. Schroeder L and Masiques N. (1982). Use of substance P fragments to differentiate substance P receptors of different tissues. Reg Pept. 2. 337–351.
Lee CM. Campbell NJ. Williams B J and Iversen L L. (1986). Multiple tachykinin binding sites in peripheral tissues and in brain. Eur J Pharmac. (In press).
Holzer P and Lembeck F. (1980). Neurally mediated contractions of ileal longitudinal muscle by substance P. Neurosci Letts. 17. 101–105.
Yau W M and Youther M L. (1982). Direct evidence for a release of acetylcholine from the myenteric plexus of guinea pig small intestine by substance P. Eur J Pharmac. 81. 665–668.
Fosbraey P. Featherstone R L and Morton I K M. (1984). Comparison of potency of substance P and related peptides on [3H]-acetylcholine release. and contractile actions. in the guinea pig ileum. Naunyn-Schmiedebergs Arch Pharmac. 326. 11l–1l5.
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© 1987 Springer-Verlag New York Inc.
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Watling, K.J., Suman-Chauhan, N., Bristow, D.R. (1987). Tachykinin-Induced Phosphatidylinositol Turnover in Hamster Urinary Bladder. In: Henry, J.L., Couture, R., Cuello, A.C., Pelletier, G., Quirion, R., Regoli, D. (eds) Substance P and Neurokinins. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4672-5_20
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DOI: https://doi.org/10.1007/978-1-4612-4672-5_20
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