Characterization of Binding of [125I]Iodohistidyl1-Substance K to Tachykinin K-Sites in Hamster Bladder

  • S. H. Buck
Conference paper


P-type and K-type tachykinin binding sites exist in variable proportions in urinary bladder of different rodent species with hamster bladder containing predominantly high amounts of K-type sites [1; Burcher and Buck, this volume]. In the present report, 125iodohistidyl1-SK (ISK) has been employed as the radioligand to examine in detail the K-sites in hamster bladder.


Urinary Bladder Rodent Species Scatchard Analysis Optimal Effect Messenger System 
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  1. 1.
    Burcher, E, Buck, SH (1986) Multiple tachykinin binding sites in hamster, rat, and guinea-pig urinary bladder. Eur. J. Pharmacol., in press.Google Scholar
  2. 2.
    Burcher, E, Buck, SH, Lovenberg, W, O’Donohue, TL (1986) Characterization and autoradiographic localization of multiple tachykinin binding sites in gastrointestinal tract and bladder. J. Pharmacol. Exp. Ther. 236 819–831.PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • S. H. Buck
    • 1
  1. 1.Div. Biochemical Sci.Merrell Dow Res. Inst.CincinnatiUSA

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