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Multiple Tachykinin Binding Sites in Rat Brain and Peripheral Tissues

  • C. M. Lee
  • C. M. Campbell
  • B. J. Williams
  • B. J. Iversen
Conference paper

Abstract

Based on the different rank order of potencies as well as the lack of complete cross-tachyphylaxis observed among different tachykinins and their analogues in several biological assays, we have previously proposed the existence of multiple subtypes of SP receptors in different tissues [1–3]. For the SP-P subtype, both physalaemin (PHY) and SP are active at nanomolar concentrations with eledoisin (E) and kassinin (KAS) more or less equipotent. On the other hand, for the SP-E subtype, KAS, E and neurokinin A (NKA) are active at nanomolar concentrations and they are several hundred times more active than PHY or SP. The distinction between SP-P and SP-E system was further delineated by the development of a SP-P selective agonist, SP-O-methyl ester (SPOMe), which is 100–1000 times less potent than substance P on SP-E systems [4].

Keywords

Nanomolar Concentration Tachykinin Receptor Substance Preceptor Dohme Research Laboratory Distinct Pharmacological Profile 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Reference

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Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • C. M. Lee
    • 1
  • C. M. Campbell
    • 1
  • B. J. Williams
    • 1
  • B. J. Iversen
    • 1
  1. 1.Merck, Sharp & Dohme Research LaboratoriesNeuroscience Research CentreHarlow, EssexEngland

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