Effects of an Amino-Terminal Fragment of Substance P on Brain Dopamine and Serotonin Metabolism

  • M. E. Hall
  • P. DeArmey
  • J. M. Stewart
Conference paper


Central or peripheral administration of substance P (SP) produces a number of effects on behavior. In mice, SP decreases isolation-induced aggressive [1] and nociceptive [2] behaviors. SP alters several measures of spontaneous motor behavior in rats and mice [3]. Intraventricular (ICIT) SP dramatically enhances groaning and scratching behavior in mice [4], but not rats [5], while locomotion, sniffing and hindlimb rearing behavior are enhanced in both species [6,7].


Dopamine Amide Serotonin Norepinephrine Carboxy 


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Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • M. E. Hall
    • 1
  • P. DeArmey
    • 1
  • J. M. Stewart
    • 1
  1. 1.Department of BiochemistryUniversity of Colorado School of MedicineDenverUSA

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