Effects of an Amino-Terminal Fragment of Substance P on Brain Dopamine and Serotonin Metabolism

  • M. E. Hall
  • P. DeArmey
  • J. M. Stewart
Conference paper


Central or peripheral administration of substance P (SP) produces a number of effects on behavior. In mice, SP decreases isolation-induced aggressive [1] and nociceptive [2] behaviors. SP alters several measures of spontaneous motor behavior in rats and mice [3]. Intraventricular (ICIT) SP dramatically enhances groaning and scratching behavior in mice [4], but not rats [5], while locomotion, sniffing and hindlimb rearing behavior are enhanced in both species [6,7].


Substantia Nigra Brain Dopamine HIAA Level Rear Behavior Amine Level 
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  1. 1.
    Hall ME, Stewart JM (1984) Modulation of isolation-induced fighting by N- and C-terminal analogs of substance P: evidence for multiple recognition sites. Peptides 5:85–89PubMedCrossRefGoogle Scholar
  2. 2.
    Hall ME, Stewart JM (1983) SUbstance P and antinociception. Peptides 4:31–35PubMedCrossRefGoogle Scholar
  3. 3.
    Hall ME, Stewart JM (1983) SUbstance P and behavior: opposite effects of N-terminal and Cterminal fragments. Peptides 4:763–768PubMedCrossRefGoogle Scholar
  4. 4.
    Share A, Rackham A (1981) Intracerebral substance P in mice: behavioral effects and narcotic agents. Brain Res 211:379–386PubMedCrossRefGoogle Scholar
  5. 5.
    Rondeau DB, Jolicoeur FB, Belanger F, Barbeau A (1978) Motor activity induced by substance P in rats. Phannacol Biochem Behav 9:769–775CrossRefGoogle Scholar
  6. 6.
    Naranjo JR, Del Rio J (1984) Locanotor activation induced in rodents by substance P and analogs. Nwrophannacol 23:1167–1171CrossRefGoogle Scholar
  7. 7.
    Stewart JM, Hall ME (1985) Effects of intraventricular substance P on motor behavior in mice: structure/activity studies. In: Jordan CC, Oehme P (eds) Substance P: metabolism and biological actions, London: Taylor and FrancisGoogle Scholar
  8. 8.
    Glowinski J, Michelot R, Cheramy A (1980) Role of striate-nigral substance P in the regulation of the activity of the nigrestriatal dopaminergic neurons. In: Costa E, Trabucchi M (eds) Neural peptides and neuronal cmmunication, New York: Raven PressGoogle Scholar
  9. 9.
    Waldmeier PC, Kam R, Stocklin K (1978) Increased dopamine metabolism in the rat striatum after infusions of substance Pinto the substantia nigra. Brain Res 159: 223–227PubMedCrossRefGoogle Scholar
  10. 10.
    Kalivas PW, Miller JS (1984) SUbstance P modulation of dopamine in the nucleus accunbens. Neurosci Lett 48: 55–59PubMedCrossRefGoogle Scholar
  11. 11.
    Forchetti CM, Marco EJ, Meek JL (1982) Serotonin and Y-amincbutyric acid turnover after injection into the median raphe of substance P and D-ala-met-enkephalin amide. J Neurochem 38:1336–1341.PubMedCrossRefGoogle Scholar
  12. 12.
    Starr M (1978) Investigation of possible interactions between substance P and transmitter mechanisms in the substantia nigra and corpus striatum of the rat. J Pharm Pharmacol 30:359–363PubMedCrossRefGoogle Scholar
  13. 13.
    Bury R, Mashford M (1976) Biological activity of C-terminal partial sequences of substance P. J Med Chem 19:854–856PubMedCrossRefGoogle Scholar
  14. 14.
    Stewart JM, Young JD (1984) Solid Phase Peptide Synthesis. Rockford, IL: Pierce Chemical Co.Google Scholar
  15. 15.
    Hall ME, Grantham P, Stewart JM (1985) Age and strain differences in sane behavioral effects of intracranial substance P. Peptides 6:363–368PubMedCrossRefGoogle Scholar
  16. 16.
    Bruning JL, Kintz BL (1977) Canputationa1 Handbook of Statistics. Glenview, IL: Scott, Foresman & Co.Google Scholar
  17. 17.
    Sakurada T, Greves P, Stewart JM, Terenius L (1985) Measurement of substance P metabolites in rat CNS. J Neurochem 44:718–722PubMedCrossRefGoogle Scholar
  18. 18.
    Matsas R, Fulcher IS, Kenny AI, Turner AI (1983) SUbstance P and [Leu]enkephalin are hydrolysed by an enzyme in pig caudate synaptic manbranes that is identical with the endopeptidase of kidney microvilli. Proc Nat Acad Sci US 80:3111–3115CrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • M. E. Hall
    • 1
  • P. DeArmey
    • 1
  • J. M. Stewart
    • 1
  1. 1.Department of BiochemistryUniversity of Colorado School of MedicineDenverUSA

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