Skip to main content
SpringerLink
Log in

Central Modulation of Blood Pressure by N- and C-Terminal Fragments of Substance P

  • Conference paper
Substance P and Neurokinins

Abstract

Recent evidence suggests that substance P (SP) may be involved in central regulation of cardiovascular function (1). SP and SP receptors are found in several brainstem structures, among them the nucleus tractus solitarius (NTS) (2, 3), which plays a major role in regulating blood pressure (bp) (4). Afferent fibers of the vagus and glossopharyngeal nerves, some containing SP (5), come from baroreceptors in the carotid sinus and aortic arch, activation of which leads to a depressor effect (fall in bp) (4). Removal of the nodose ganglion leads to a decline in the SP content of those regions of the NTS that receive baroreceptor afferents (6).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 74.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Palkovitz M (1981) Neurcpeptides and biogenic amines in central cardiovascular control mechanisms. In: Buckley JP, Farrario CM (eds) Central nervous system mechanisms in hypertension, New York: Raven Press

    Google Scholar 

  2. Helke CJ (1982) Neuroanatanical localization of substance P: inplications for central cardiovascular control. Peptides 3:479–483

    Article  PubMed  CAS  Google Scholar 

  3. Rothman RB, Herkenham M, Pert CB, Liang T, Cascieri, MA (1984) Visualization of rat brain receptors for the neuropeptide, substance P. Brain Res 309:47–54

    Article  PubMed  CAS  Google Scholar 

  4. Loewy AD (1982) Central cardiovascular pathways. In: Smith OA, Galosy RA, Weiss SM (eds) Circulation, Neurobiology and Behavior. Amsterdam: Elsevier

    Google Scholar 

  5. Cuello AC, Kanazawa I (1978) The distribution of substance P immunoreactive fibers in the rat central nervous system. J Camp Neurol 178:129–156

    Article  CAS  Google Scholar 

  6. Helke CJ, O’Donohue TL, Jacobowitz DM (1980) Substance P as a baro- and chemoreceptor afferent neurotransmitter: immunocytochemical and neurochemical evidence in the rat. Peptides 1: 1–9

    Article  PubMed  CAS  Google Scholar 

  7. Fuxe K, Agnati LF, Ganten D, Goldstein M, Yukimura T, Jonnson G, Bolme P, Hokfelt T, Andersson A, Haefstrand A, Unger T, Rascher W (1981) The role of noradrenaline and adrenaline neuron systems and substance P in the control of central cardiovascular functions. In: Buckley JP, Farrario CM (eds) Central Nervous system Mechanisms in Hypertension. New York: Raven Press

    Google Scholar 

  8. Unger T, Rockhold RW, Yukimura T, Rettig R, Rascher W, Ganten D (1981) Role of kinins and substance P in the central blood pressure regulation of normotensive and spontaneously hypertensive rats. Ibid

    Google Scholar 

  9. Traczyk WZ, Kubicki J (1980) The pressor response to substance P and hexapeptide [pGlu6]SP(6–11) injections into the cerebral ventricles in rats. Neuropharmacol 19:607–611

    Article  CAS  Google Scholar 

  10. Haeusler G, Osterwalder R (1980) Evidence suggesting a transmitter or neuranodulatory role for substance P at the first synapse of the baroreceptor reflex. Naunyn-Schmiedeberg’s Arch. Pharmacol 314:111–121

    CAS  Google Scholar 

  11. Talman W, Reis D (1981) Baroreflex actions of substance P microinjected into the nucleus tractus solitarii in rat: a consequence of local distortion. Brain Res 220:402–407

    Article  PubMed  CAS  Google Scholar 

  12. Carter D, Lightman SL (1985) Cardiorespiratory actions of substance P, TRH and 5-HT in the nucleus tractus solitarius of rats: evidence for functional interactions of neuropeptides and amine neurotransmitters. Neuropeptides 6:425–436

    Article  PubMed  CAS  Google Scholar 

  13. Bury R, Mashford M (1976) Biological activity of C-ter:rninal partial sequences of substance P. J Med Chem 19:854–856

    Article  PubMed  CAS  Google Scholar 

  14. Gaffori O, Stewart JM, DeWied D (1984) Influence of substance P and fragments on passive avoidance behavior. Fxperientia, 40:89–91

    Article  CAS  Google Scholar 

  15. Hall ME, Stewart JM (1984) Modulation of isolation-induced fighting by N- and Cterminal analogs of substance P: evidence for multiple recognition sites. Peptides 5:85–89

    Article  PubMed  CAS  Google Scholar 

  16. Stewart JM, Hall ME (1985) Effects of intraventricular substance P on motor behavior in mice: structure/activity studies. In: Jordan CC, Oehme P. (eds) Substance P Metabolism and Biological Actions. London: Taylor & Francis

    Google Scholar 

  17. Hall ME, DeArmey P, Pelleymounter MA, Stewart JM (1985) Effects of substance P (SP) and SP fragments on brain amine metabolism as determined by HPLC with electrochemical detection. Neurosci. Abstr 11:884

    Google Scholar 

  18. Stewart JM, Young JD (1984) Solid Phase Pep-tide Synthesis. Rockford, IL: Pierce Chemical Co.

    Google Scholar 

  19. Charlton CG, Helke CJ (1985) Characterization and segmental distribution of 125I-Bolton-Hunter labeled substance P binding sites in rat spinal cord. J Neurosci 5:1653–1661

    PubMed  CAS  Google Scholar 

  20. Yashpal T, Gauther, SG, Henry JL (1985) Substance P given intrathecally at the spinal T9 level increases adrenal output of adrenaline and noradrenaline in the rat. Neurosci 15:529–536

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, University of Colorado School of Medicine, 80262, Denver, Colorado, USA

    I. M. Stewart, F. Miley & M. E. Hall

Authors
  1. I. M. Stewart
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. Miley
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. E. Hall
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Physiology, McGill University, Montreal, Quebec, H3G 1Y6, Canada

    James L. Henry Ph.D.

  2. Department of Physiology, University of Montreal, C.P. 6208, Montreal, Quebec, H3C 3T8, Canada

    Rejean Couture Ph.D.

  3. Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, H3G 1Y6, Canada

    A. Claudio Cuello M.D.

  4. MRC Group in Molecular Endocrinology, Centre Hospitalier de L’Universite, Laval, Quebec, G1V 4G2, Canada

    Georges Pelletier Ph.D.

  5. Douglas Hospital Research Centre and Department of Psychiatry, McGill University, Verdun, Quebec, H4H 1R3, Canada

    Remi Quirion Ph.D.

  6. Department of Pharmacology, Medical School, University of Sherbrooke, Sherbrooke, Quebec, J1H 5N4, Canada

    Domenico Regoli M.D.

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer-Verlag New York Inc.

About this paper

Cite this paper

Stewart, I.M., Miley, F., Hall, M.E. (1987). Central Modulation of Blood Pressure by N- and C-Terminal Fragments of Substance P. In: Henry, J.L., Couture, R., Cuello, A.C., Pelletier, G., Quirion, R., Regoli, D. (eds) Substance P and Neurokinins. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4672-5_103

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-4672-5_103

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-9109-1

  • Online ISBN: 978-1-4612-4672-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation