Substance P and Neurokinins

  • S. E. Leeman
Conference paper


In 1931[1] von Euler and Gaddum reported the presence of a hypotensive substance in extracts of brain and intestine that could stimulate the contraction of various isolated smooth muscles. The active principle in these preparations, a peptide, was later termed substance P. In 1970 [2] Chang and Leeman isolated a sialogogic peptide and soon thereafter characterized it as substance P by multiple biological and chemical criteria.


Peptide Substance Chemical Criterion Massachusetts Medical School Radio Immunoassay Drug Manipulation 
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Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • S. E. Leeman
    • 1
  1. 1.Dept. of PhysiologyUniversity of Massachusetts Medical SchoolWorcesterUSA

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