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Substance P and Neurokinins

  • S. E. Leeman
Conference paper

Abstract

In 1931[1] von Euler and Gaddum reported the presence of a hypotensive substance in extracts of brain and intestine that could stimulate the contraction of various isolated smooth muscles. The active principle in these preparations, a peptide, was later termed substance P. In 1970 [2] Chang and Leeman isolated a sialogogic peptide and soon thereafter characterized it as substance P by multiple biological and chemical criteria.

Keywords

Peptide Substance Chemical Criterion Massachusetts Medical School Radio Immunoassay Drug Manipulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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    Euler, VS von, Gaddum, JH (193) J Physiol (Lond) 72: 74–87Google Scholar
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Copyright information

© Springer-Verlag New York Inc. 1987

Authors and Affiliations

  • S. E. Leeman
    • 1
  1. 1.Dept. of PhysiologyUniversity of Massachusetts Medical SchoolWorcesterUSA

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