Abstract
A functional deficiency of the trace amines β-phenylethylamine (PE) and tryptamine (T) in depressive disorders has been suggested by a number of researchers (Dewhurst, 1968; Boulton and Milward, 1971; Fischer et al., 1972; Sabelli and Mosnaim, 1974), and one of the most pronounced effects seen in the brains of laboratory animals after administration of most monoamine oxidase (MAO)-inhibiting antidepressants is a marked increase in concentrations of PE and T (Boulton, 1976; Philips and Boulton, 1979; McKim et al., 1980). It has also been demonstrated that administration of either of these amines to rodents produces marked behavioural effects (Dewhurst, 1968; Dourish, 1982, 1984; Greenshaw, 1984).
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Baker, G.B., Coutts, R.T., Rao, T.S., Hall, T.W.E., Micetich, R.G. (1988). Prodrugs of β-Phenylethylamine and Tryptamine: Studies in the Rat. In: Boulton, A.A., Juorio, A.V., Downer, R.G.H. (eds) Trace Amines. Experimental and Clinical Neuroscience. Humana Press. https://doi.org/10.1007/978-1-4612-4602-2_30
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DOI: https://doi.org/10.1007/978-1-4612-4602-2_30
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