Abstract
An animal test for hallucinogenic activity in man could be a valuable aid in the choice or rejection of psychoactive compounds for clinical use. Since it is impossible to determine whether an animal is experiencing hallucinations or not, an attempt to predict whether a drug, which has not been tested in humans, is likely to be hallucinogenic must be based on correlation between the hallucinogenic activity of known drugs and a measurable specific effect in animals (Corne and Pickering, 1967). Such correlations have been studied for a variety of hallucinogens in many animal species. Previous attempts to study correlation between animal tests and hallucinogenic activity have either required more than one test to encompass the different chemical structures or have been restricted to correlations within a specific chemical series.
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References
Clay, G.A. Cho, A.K. and Roberfroid, M. (1971). Effect of SKF-525A on the norepinephrine-depleting actions of d-amphetamine. Biochem. Pharmacol. 20, 1821-1831.
Clineschmidt, B.V. and Lotti, V.J. (1974). Indole antagonists: Relative potencies as inhibitors of tryptamine and 5-HTP-induced responses. Br. J. Pharmacol. 50, 311-313.
Corne, S.J. Pickering, R.W. and Warner, B.T.(1963). A method for assessing the effects of drugs on the central actions of 5-HT. Br. J. Pharmacol. 20, 106-120.
Corne, S.J. and Pickering, R.W. (1967). A possible correlation between drug-induced hallucinations in man and a behavioural response in mice. Psychophantacol. 11, 65-78.
Handley, S.L. and Brown, J. (1982). Effects of the 5-hydroxytryptamine-induced head-twitch of drugs with selective actions on alpha1- and alpha2-adrenoceptors. Neuro-Pharmacol. 21, 507-510.
Kinemuchi, H. Fowler, C.J. and Tipton, K.F. (1984). Substrate specificities of the two forms of monoamine oxidase. In Monoamine oxidase and disease (Tipton, K.F. Dostert, P. and Strolin Benedetti, M., eds), pp. 53-62. Academic Press, New York.
Malick, J.B. Doren, E. and Barnett, A. (1977). Quipazine-induced head-twitch in mice. Pharmacol. Biochem. Behav. 6, 325-329.
Nakamura, M. and Fukushima, H. (1978). Effects of reserpine, para-chlorophenylalanine, 5,6-dihydroxytryptamine and f ludiazepam on the head-twitches induced by 5-hydro-xytryptamine or 5-methoxytryptamine in mice. J. Pharm. Pharmacol. 30, 254-256.
Oreland, L. Arai, Y. and Stenstrom, A. (1983). The effect of deprenyl (selegyline) on intra- and extraneuronal dopamine oxidation. Acta Neurol. Scand. suppl 95, 81-85.
Orikasa, S. Sakurada, S. and Kisara, K. (1980). Head-twitch response induced by tyramine. PsychoPharmacol. 67, 53-59.
Sakurada, S. (1975). Central action of beta-pheny le thy la-mine derivatives (6). Head-twitches induced by intracerebraly administered tyramine in isocarboxazid pretreated mice. Folia pharmacol. japon. 71, 779-787.
Satoh, S. Satoh, N. Tadano, T. and Kisara, K. (1985). Enhancement of para-hydroxyamphetamine induced head-twitch response by catecholamine depletion. Res. Commun. Sub. Abuse 6, 213-219.
Tadano, T. Satoh, S. and Kisara, K. (1986). Head-twitches induced by p-hydroxyamphetamine in mice. Japan. J. Pharmacol. 41, 519-523.
Tadano, T, Satoh, S. Satoh, N. Kisara, K. Arai, Y. and Kinemuchi, H. (1987). Involvement of alpha-adrenoceptors in para-hydroxy amphetamine-induced head-twitch response. Psychopharmacol. in press.
Taylor, W.A. and Sulser, F. (1973). Effects of amphetamine and its hydroxylated metabolites on central noradrenergic mechanisms. J. Pharm. Exp. Ther. 185, 620-632.
Vetulani, J. Bednarczyk, B. Reichenburg, K. and Rokosz, A. (1980). Head-twitches induced by LSD and quipazine. Neuropharroacol. 19, 155-158.
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© 1988 The Humana Press Inc.
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Satoh, N. et al. (1988). The Role of Form a Monoamine Oxidase in Head-Twitch Response Induced by Para-Hydroxyamphetamine. In: Boulton, A.A., Juorio, A.V., Downer, R.G.H. (eds) Trace Amines. Experimental and Clinical Neuroscience. Humana Press. https://doi.org/10.1007/978-1-4612-4602-2_22
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DOI: https://doi.org/10.1007/978-1-4612-4602-2_22
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