Trace Amines pp 191-199 | Cite as

Involvement of Newly Synthetized Catecholamines in the Modulation by Trace Amines of the Release of Neurotransmitters

  • Salomon Z. Langer
  • Sonia Arbilla
Part of the Experimental and Clinical Neuroscience book series (ECN)


The receptor mediated modulation of the release of 3H-neurotransmitters from slices of selected brain areas or from peripheral tissues is a well-established model to study interactions between neurotransmitters (Langer, 1981; Langer and Arbilla, 1981).


Substantia Nigra Transmitter Release Corpus Striatum Tyrosine Hydroxylase Activity Trace Amine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Arbilla S., Nowak J.Z. and Langer S.Z. (1985) Rapid desensitization of presynaptic dopamine autoreceptors during exposure to exogenous dopamine. Brain. Res. 337, 11–17.PubMedCrossRefGoogle Scholar
  2. Baud P., Arbilla S. and Langer S.Z. (1985) Inhibition of the electrically evoked release of 3H-acetylcholine in rat striatal slices: an experimental model for drugs that enhance dopaminergic neurotransmission. J. Neurochem. 44, 331–337.PubMedCrossRefGoogle Scholar
  3. Benkirane S., Arbilla S. and Langer S.Z. (1986a) Phenyl-ethylamine-induced release of noradrenaline fails to stimulate α1-adrenoceptors modulating 3H-acetylcholine release in the rat atria, but activates α2-adrenoceptors modulating 3H-serotonin release in the hippocampus. Naunyn-Schmi edeqerq’s Arch. Pharmacol. 334, 149–155.Google Scholar
  4. Benkirane S., Arbilla S. and Langer S.Z. (1986b) Newly synthesized noradrenaline mediates the α2-adreno-ceptor inhibition of 3H-5-hydroxytryptamine release induced by β-phenylethylamine in rat hippocampal slices. Eur. J. Pharmacol. 131, 189–198.PubMedCrossRefGoogle Scholar
  5. Benkirane S., Arbilla S. and Langer S.Z. (1987) A functional response to D1 dopamine receptor stimulation in the central nervous system: inhibition of the release of 3H-serotonin from the rat substantia nigra. Naunyn-Schmi edeqerq’s Arch. Pharmacol. 335, 502–507.Google Scholar
  6. Lehmann J. and Langer S.Z. (1983) Dopamine receptors modulating 3H-acety1choline release in slices of the cat caudate: effects of (-)N-(2-chloroethyl)nora-pomorphine. Eur. J. Pharmacol. 90, 393–400.PubMedCrossRefGoogle Scholar
  7. Langer S.Z. (1981) Presynaptic regulation of the release of catecholamines. Pharmac. Rev. 32, 337–362.Google Scholar
  8. Langer S.Z. and Arbilla S. (1981) Presynaptic receptors and modulation of the release of noradrenaline, dopamine and GABA. Postgraduate Medical Journal 57, 18–29.PubMedGoogle Scholar
  9. Langer S.Z., Arbilla S., Niddam R., Benkirane S. and Baud P. (1985) Pharmacological profile of β-phenyl-ethylamine on dopaminergic and noradrenergic neurotransmission in rat cerebral slices: comparison with amphetamine and other trace amines. In, Neuropsycho-pharmacology of the trace amines (Boulton A.A., Maitre L., Bieck P.R. and Reiderer P., ed) pp 27–88, Humana Press, Inc. Clifton N.J.Google Scholar
  10. Westlund K.N., Denney R.M., Kocherspergen L.M., Rose R.M. and Abell C.W. (1985) Distinct monoamine oxidase A and B population in the primate brain. Science 230, 181–183PubMedCrossRefGoogle Scholar
  11. Yang H.Y.T. and Neff N.H. (1973) β-Phenylehtylamine: a specific substrate for type B monoamine oxidase of brain. J. Pharmacol. Exp. Ther. 187, 365–371.PubMedGoogle Scholar

Copyright information

© The Humana Press Inc. 1988

Authors and Affiliations

  • Salomon Z. Langer
    • 1
  • Sonia Arbilla
    • 1
  1. 1.Department of BiologyLaboratoires d’Etudes et de Recherches Synthélabo (L.E.R.S.)ParisFrance

Personalised recommendations