Structural Effects in the Self-Association of γ II-Crystallin
The eye lens is a proteic glass, the properties of which depend on the supramolecular organization of lens specific proteins, the α-, β- and γ-crystallins (1). In order to understand this proteic system, it is necessary first to describe the intermolecular interactions among crystallins and then consider the behavior of this complex framework in normal and/or pathological states, e.g. cataracts (1). Such interactions are of importance in driving the steric arrangement of the proteins inside the lens.
KeywordsCircular Dichroism Supramolecular Organization Complex Framework Concentration Difference Spectrum Aromatic Chromophore
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- 1.Molecular and Cellular Biology of the Eye Lens (1981) (Bloemendal, H., ed.) J. Wiley, New York.Google Scholar
- 5.Chen, R.F., Edelhoch, H. and Steiner, R.F. (1969) in: Physical Principles and Techniques of Protein Chemistry (Leach, S.J., ed.) pp. 171–244, Academic Press, New York.Google Scholar