Abstract
Metachromatic staining is a property of basophils and mast cells due to the proteoglycan content of their granules. Proteoglycans are the most distinctive constituent of mast cell or basophil granules and the glycosaminoglycan component is responsible for the specific metachromatic dye binding (1). Mast cells and basophils are involved through their high affinity IgE receptors in allergic or immediate type hypersensitivity reactions. It has also been recognized that basophils or mast cells participate in a wide range of inflammatory and immune reactions but the mechanism whereby these cells accumulate in tissues or gain access to sites of inflammation is poorly understood. In allergy, antigen may act not only to promote inflammatory reactions, which result in chemotactic signals for mature basophils or mast cells to accumulate locally but could also stimulate the production of factors from peripheral blood cells (PBL) or from locally situated cells for the progenitor cells to promote their growth and differentiation into effector cells.
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Stadler, B.M., Brantschen, S., Hirai, K., Nakajima, K., Walz, A., de Wedk, A.L. (1987). Growth and Differentiation Factors for Human Metachromatically Staining Cells. In: Webb, D.R., Pierce, C.W., Cohen, S. (eds) Molecular Basis of Lymphokine Action. Experimental Biology and Medicine, vol 18. Humana Press. https://doi.org/10.1007/978-1-4612-4598-8_35
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DOI: https://doi.org/10.1007/978-1-4612-4598-8_35
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