Lymphokine Production in Autoimmunity: Usefulness of mRNA Assays
Recent studies have emphasized the similarity of autoimmune responses to those occuring against extrinsic antigens. In autoimmune diseases such as Graves’ disease, T lymphocytes are activated by tissue cells expressing HLA class II antigens presenting their autoantigens to autoreactive T cells. More commonly antigen presenting cells expressing HLA class II activate T cells recognizing extrinsic antigens. Since it has been amply demonstrated that class II expression is regulated by lymphokines such as Interferon γ, it is apparent that the regulation of lymphokine production in autoimmunity needs to be understood.
KeywordsArthritis Interferon Prostaglandin Half Life Collagenase
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