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Lymphokine Production in Autoimmunity: Usefulness of mRNA Assays

  • Marc Feldmann
  • Ravinder N. Maini
  • Marco Londei
  • Kathy Barrett
  • Martin Turner
  • Glenn Buchan
Part of the Experimental Biology and Medicine book series (EBAM, volume 18)

Abstract

Recent studies have emphasized the similarity of autoimmune responses to those occuring against extrinsic antigens. In autoimmune diseases such as Graves’ disease, T lymphocytes are activated by tissue cells expressing HLA class II antigens presenting their autoantigens to autoreactive T cells. More commonly antigen presenting cells expressing HLA class II activate T cells recognizing extrinsic antigens. Since it has been amply demonstrated that class II expression is regulated by lymphokines such as Interferon γ, it is apparent that the regulation of lymphokine production in autoimmunity needs to be understood.

Keywords

Rheumatoid Arthritis Synovial Fluid Cell Clone mRNA Production Slot Blot Analysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Humana Press Inc. 1987

Authors and Affiliations

  • Marc Feldmann
    • 1
  • Ravinder N. Maini
    • 2
  • Marco Londei
    • 1
  • Kathy Barrett
    • 1
  • Martin Turner
    • 1
  • Glenn Buchan
    • 1
  1. 1.Charing Cross Sunley Research CentreHammersmith, LondonUK
  2. 2.Kennedy Institute of RheumatologyHammersmith, LondonUK

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