Lymphokine Production in Autoimmunity: Usefulness of mRNA Assays
Recent studies have emphasized the similarity of autoimmune responses to those occuring against extrinsic antigens. In autoimmune diseases such as Graves’ disease, T lymphocytes are activated by tissue cells expressing HLA class II antigens presenting their autoantigens to autoreactive T cells. More commonly antigen presenting cells expressing HLA class II activate T cells recognizing extrinsic antigens. Since it has been amply demonstrated that class II expression is regulated by lymphokines such as Interferon γ, it is apparent that the regulation of lymphokine production in autoimmunity needs to be understood.
KeywordsRheumatoid Arthritis Synovial Fluid Cell Clone mRNA Production Slot Blot Analysis
Unable to display preview. Download preview PDF.
- Acres, R., Larsen, A., Gillis, S. and Conlon, P. (1986) 6th International Congress of Immunology (Abstracts) page 176.Google Scholar
- Buchan, G., Barrett, K., Maini, R.N. and Feldmann, M. (1987) Nature (submitted).Google Scholar
- Londei, M., Grubeck-Loebenstein, B., de Berardinis, P., Greenall, C. and Feldmann, M. (1987) J. Clin. Invest. (submitted).Google Scholar
- Saklatvala, J., Pilsworth, L., Sarsfield, S., Gavrilovic, J. and Heath, J. (1984) J. Biochem. 224, 461–466.Google Scholar
- Turner, M., Buchan, C, Barrett, K. and Feldmann, M. (1986) Br. J. Rheum. 25 (Abst. Suppl. 2).Google Scholar