Life after IL2
Upon interaction with interleukin 2 and antigen, a precursor cyto - toxic T lymphocyte (pCTL) undergoes the final steps of differentiation to become an activated killer cell capable of binding to and lysing antigen bearing target cells. In response to these stimuli, a variety of genes are upregulated including those which encode the IL2-receptor (Kronke et al., 1985), the receptors for transferrin and insulin (Neckers and Cossman, 1983), the c-myc protein (Kelly et al., 1983), and MHC molecules (Cotner et al., 1983). These gene products play important roles in cell growth, cycling and communication, however they are not directly involved in the cytolytic machinery of activated CTL.
KeywordsSerine Protease Target Cell Membrane Murine Spleen Chromium Release Assay Active Site Serine
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