Suppressor T Cell Receptor and Functional Molecule
The T cell antigen-receptor on helper and cytotoxic T lymphocytes (CTL) have been identified to be a cell surface heterodimer consisting of alpha and beta chains which are encoded by alpha and beta genes1–3.No structural differences have however been demonstrated between helper and CTL receptors, despite their distinct biological activities. This indicates that functional molecule and antigen receptor are different in these T cells. Thus, mechanisms of expression of functional activity after activation of T cells through antigen receptor is unknown. On the other hand, there exists suppressor T cells (Ts) that negatively regulate immune responses in an antigen specific and MHC restricted manner. The function has been demonstrated to be mediated through soluble suppressor T cell factor (TsF), while their antigen receptor has not yet been identified. Therefore, suppressor T cell factor provides a useful tool for understanding the relationship between recognition and function of T cells.
KeywordsAntigen Receptor Translation Product Keyhole Limpet Hemocyanin Alpha Chain Beta Chain
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