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Suppressor T Cell Receptor and Functional Molecule

  • Masaru Taniguchi
  • Eiki Matsushita
  • Kenji Imai
  • Akihiko Koseki
  • Takayuki Sumida
  • Toshitada Takemori
  • Toshihiro Ito
  • Shuichi Yamamoto
  • Masamoto Kanno
Part of the Experimental Biology and Medicine book series (EBAM, volume 18)

Abstract

The T cell antigen-receptor on helper and cytotoxic T lymphocytes (CTL) have been identified to be a cell surface heterodimer consisting of alpha and beta chains which are encoded by alpha and beta genes1–3.No structural differences have however been demonstrated between helper and CTL receptors, despite their distinct biological activities. This indicates that functional molecule and antigen receptor are different in these T cells. Thus, mechanisms of expression of functional activity after activation of T cells through antigen receptor is unknown. On the other hand, there exists suppressor T cells (Ts) that negatively regulate immune responses in an antigen specific and MHC restricted manner. The function has been demonstrated to be mediated through soluble suppressor T cell factor (TsF), while their antigen receptor has not yet been identified. Therefore, suppressor T cell factor provides a useful tool for understanding the relationship between recognition and function of T cells.

Keywords

Antigen Receptor Translation Product Keyhole Limpet Hemocyanin Alpha Chain Beta Chain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© The Humana Press Inc. 1987

Authors and Affiliations

  • Masaru Taniguchi
    • 1
  • Eiki Matsushita
    • 1
  • Kenji Imai
    • 1
  • Akihiko Koseki
    • 1
  • Takayuki Sumida
    • 1
  • Toshitada Takemori
    • 1
  • Toshihiro Ito
    • 1
  • Shuichi Yamamoto
    • 1
  • Masamoto Kanno
    • 1
  1. 1.Department of Immunology, School of MedicineChiba UniversityChibaJapan

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