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Molecular Basis of Lymphokine Action pp 137–148Cite as

Current Studies Examining Regulation of the Human B Cell Cycle

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Part of the book series: Experimental Biology and Medicine ((EBAM,volume 18))

Abstract

The study of human B cell physiology involves the evaluation of a wide array of functions performed by B lymphocytes including antigen presentation (1), maintenance of memory for antigen (2), lymphokine secretion (3–5), and Ig production. Clearly B cells influence the functioning of other cells as much as they are regulated by cell contact with and cytokines produced by various cell types. In this review we will focus on work done recently in our laboratory examining the role of certain mediators and their receptors in regulating the progression of human B lymphocytes from the resting state to Ig producing plasma cells. This can roughly be divided into stages of activation, proliferation and differentiation (6–7).

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Author information

Authors and Affiliations

  1. NIAID, National Institutes of Health, Bethesda, Maryland, USA

    Anthony S. Fauci

Authors
  1. Julian L. Ambrus Jr.
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  2. Anthony S. Fauci
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Editor information

Editors and Affiliations

  1. Roche Institute of Molecular Biology, Nutley, New Jersey, USA

    David R. Webb

  2. Jewish Hospital, Washington University, St. Louis, USA

    Carl W. Pierce

  3. University of Connecticut, Farmington, Connecticut, USA

    Stanley Cohen

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© 1987 The Humana Press Inc.

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Ambrus, J.L., Fauci, A.S. (1987). Current Studies Examining Regulation of the Human B Cell Cycle. In: Webb, D.R., Pierce, C.W., Cohen, S. (eds) Molecular Basis of Lymphokine Action. Experimental Biology and Medicine, vol 18. Humana Press. https://doi.org/10.1007/978-1-4612-4598-8_13

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  • DOI: https://doi.org/10.1007/978-1-4612-4598-8_13

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8943-2

  • Online ISBN: 978-1-4612-4598-8

  • eBook Packages: Springer Book Archive

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