Molecular structure and immunological function of human B cell differentiation factor (BSF2)
Extensive studies have been done on the factors responsible for the regulation of growth and differentiation of B lymphocytes and the involvement of several distinct factors in the process has been demonstrated (see review 1,2). These factors can be categorized into three groups; i) factors responsible for the activation of resting B cells, ii) factors for the growth and differentiation of activated B cells and iii) factors for the final differentiation of B cells into high-rate Ig-secreting cells. On the basis of the studies done by several investigators, I proposed the three signal model for the differentiation of B cells into antibody secreting cells in a previous review (2); i) anti-Ig or antigen together with BSF1 (IL-4) activate resting B cells at Go stage into G1 phase, ii) activated B cells become responsive to BCGFII which induces proliferation and Ig secretion in activated B cells and iii) BSF2 (BCDF) induces final maturation of B cells into high-rate Ig secreting cells (Fig.1).
KeywordsCOS7 Cell Cardiac Myxoma Partial Amino Acid Sequence Cell Differentiation Factor Lysyl Endopeptidase
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