Advertisement

Sequence-Specific DNA Methylation: Promoter Inactivation and Release of the Expression Block

  • Dagmar Knebel
  • Klaus-Dieter Langner
  • Arnd Hoeveler
  • Ursula Lichtenberg
  • Bernd Weisshaar
  • Doris Renz
  • Walter Doerfler
Chapter
Part of the Experimental Biology and Medicine book series (EBAM, volume 17)

Abstract

In the chemical, though by no means genetic, monotony of nucleotide sequences in DNA, the function of the modified base 5-methyl-cytosine (5-mC) poses an exciting challenge to the investigator. This enigmatic signal may affect more than one elementary mechanism in the molecular biology of eukaryotic cells. In recent years, the influence of sequence-specific promoter methylations on the regulation of gene transcription has been studied in considerable detail.

Keywords

Promoter Methylation Viral Promoter Xenopus Laevis Oocyte Autographa Californica Nuclear Polyhedrosis Virus Human Adenovirus Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Razin, A., Cedar, H., Riggs, A.D. (eds) (1984) DNA Methylation. Biochemistry and Biological Significance, Springer Verlag, New York, Berlin, Heidelberg, TokyoGoogle Scholar
  2. 2.
    Taylor, J.H. (1984) DNA Methylation and Cellular Differentiation, Springer Verlag, Wien, New YorkGoogle Scholar
  3. 3.
    Trautner, T.A. (ed) (1984) Methylation of DNA, Springer Verlag, Berlin, Heidelberg, New York, TokyoGoogle Scholar
  4. 4.
    Adams, R.L.T., and Burton, R.H. (1985) Molecular Biology of DNA Methylation. Springer Series in Molecular Biology, Springer Verlag, Berlin, Heidelberg, New YorkCrossRefGoogle Scholar
  5. 5.
    Cantoni, G.L., and Razin, A. (eds) (1985) Biochemistry and Biology of DNA Methylation, Alan R. Liss, Inc., New YorkGoogle Scholar
  6. 6.
    Borchardt, R.T., Creveling, C.R., and Ueland, P.M. (eds) (1986) Biological Methylation and Drug Design, Humana Press Clifton, N.J.Google Scholar
  7. 7.
    Doerfler, W. (1981) J. Gen. Virol. 57, 1–20PubMedCrossRefGoogle Scholar
  8. 8.
    Doerfler, W. (1983) Ann. Rev. Biochem. 52, 93–124PubMedCrossRefGoogle Scholar
  9. 9.
    Doerfler, W. (1984a), in Advances in Viral Oncology (Klein, G., ed) Vol. 4, pp. 217–247, Raven Press, New YorkGoogle Scholar
  10. 10.
    Doerfler, W. (1984b) in Methylation of DNA. Current Topics in Microbiology and Immunology (Trautner, T.A., ed) Vol. 108, pp. 79–98, Springer Verlag, Berlin, Heidelberg, New York, TokyoGoogle Scholar
  11. 11.
    Doerfler, W. (1986) in Oncogenes and Growth Control (Kahn, P., and Graf, T., eds) pp. 235–240, Springer Verlag, Berlin, Heidelberg, New York, London, Paris, TokyoGoogle Scholar
  12. 12.
    Doerfler, W., Langner, K.-D., Kruczek, I., Vardimon, L., and Renz, D. (1984) in DNA Methylation. Biochemistry and Biological Significance (Razin, A., Cedar, H., and Riggs, A.D., eds) pp. 221–247, Springer Verlag, Berlin, Heidelberg, New York, TokyoGoogle Scholar
  13. 13.
    Doerfler, W., Langner, K.-D., Knebel, D., Weyer, U., Dobrzanski, P., and Knust-Kron, B. (1985) in Biochemistry and Biology of DNA Methylation (Cantoni, G.L., and Razin, A., eds) pp. 133–155, Alan R. Liss, Inc., New YorkGoogle Scholar
  14. 14.
    Doerflerf W., Langner, K.-D., Knebel, D., and Weyer, U. (1986) in Biological Methyla-tion and Drug Design (Borchardt, R.T., Creveling, C.R., and Ueland, P.M., eds) pp. 139–150, Humana Press, Clifton, N.J.Google Scholar
  15. 15.
    Vardimon, L., Kressmann, A., Cedar, H., Maechler, M., and Doerfler, W. (1982) Proc. Natl. Acad. Sci. USA 79, 1073–1077PubMedCrossRefGoogle Scholar
  16. 16.
    Kruczek, I. and Doerfler, W. (1983) Proc. Natl. Acad. Sci. USA 80, 7586–7590PubMedCrossRefGoogle Scholar
  17. 17.
    Langner, K.-D., Vardimon, L., Renz, D., and Doerfler, W. (1984) Proc. Natl. Acad. Sci. USA 81, 2950–2954PubMedCrossRefGoogle Scholar
  18. 18.
    Langner, K.-D., Weyer, U., and Doerfler, W. (1986) Proc. Natl. Acad. Sci. USA 83, 1498–1602CrossRefGoogle Scholar
  19. 19.
    Knebel, D., Lübbert, H., and Doerfler, W. (1985) EMBO J. 4, 1301–1306PubMedGoogle Scholar
  20. 20.
    Cook, J.L., and Lewis, A.M., Jr. (1979) Cancer Res. 39, 1455–1461PubMedGoogle Scholar
  21. 21.
    Vardimon, L., Neumann, R., Kuhlmann, I., Sutter, D., and Doerfler, W. (1980) Nucleic Acids Res. 8, 2461–2473PubMedCrossRefGoogle Scholar
  22. 22.
    Johansson, K., Persson, H., Lewis, A.M., Pettersson, U., Tibbetts, C, and Philipson, L. (1978) J. Virol. 27, 628–639PubMedGoogle Scholar
  23. 23.
    Esche, H. (1982) J. Virol. 41, 1076–1082PubMedGoogle Scholar
  24. 24.
    Knebel, D., and Doerfler, W. (1986) J. Mol. Biol. 189, 371–375PubMedCrossRefGoogle Scholar
  25. 25.
    Busslinger, M., Hurst, J., and Flavell, R.A. (1983) Cell 34, 197–206PubMedCrossRefGoogle Scholar
  26. 26.
    Murray, E., and Grosveld, F. (1985) in Biochemistry and Biology of DNA Methylation (Cantoni, G.L., and Razin, A., eds) pp. 157–176, Alan R. Liss, Inc., New YorkGoogle Scholar
  27. 27.
    Keshet, I., Yisraeli, J., and Cedar, H. (1985) Proc. Natl. Acad. Sci. USA 82, 2560–2564PubMedCrossRefGoogle Scholar
  28. 28.
    Dynan, W.S., and Tjian, R. (1985) Nature 316, 774–778PubMedCrossRefGoogle Scholar
  29. 29.
    McKnight, S., and Tjian, R. (1986) Cell 46, 795–805PubMedCrossRefGoogle Scholar
  30. 30.
    Smith, S.S., and Thomas, CA., Jr. (1981) Gene 13, 395–408PubMedCrossRefGoogle Scholar
  31. 31.
    Eick, D., Fritz, H.-J., and Doerfler, W. (1983) Anal. Biochem. 135, 165–171PubMedCrossRefGoogle Scholar
  32. 32.
    Hoeveler, A., and Doerfler, W. (1987) submittedGoogle Scholar
  33. 33.
    Keshet, I., Lieman-Hurwitz, J., and Cedar, H. (1986) Cell 44, 535–543PubMedCrossRefGoogle Scholar
  34. 34.
    Gjerset, R.A., and Martin, D.W., Jr. (1982) J. Biol. Chem. 257, 8581–8583PubMedGoogle Scholar
  35. 35.
    Razin, A., Szyf, M., Kafri, T., Roll, M., Gilohf H., Scarpa, S., Carotti, D., and Cantoni, G.L. (1986) Proc. Natl. Acad. Sci. USA 83, 2827–2831PubMedCrossRefGoogle Scholar
  36. 36.
    Graham, F.L., Smiley, J., Russell, W.C., and Nairn, R. (1977) J. Gen. Virol. 36, 59–72PubMedCrossRefGoogle Scholar
  37. 37.
    Visser, L., Maarschalkerweerd, M.W., Rozjin, T.H., Wassenaar, A.D.C., Reemst, A.M.C.B., and Sussenbach, J.S. (1979) Cold Spring Harbor Symp. Quant. Biol. 44, 541–550Google Scholar
  38. 38.
    Klimkait, T., and Doerfler, W. (1985) J. Virol. 55, 466–474PubMedGoogle Scholar
  39. 39.
    Weisshaar, B., Knust, B., Langner, K.-D., Jüttermann, R., Zock, C, and Doerfler, W. (1987) submittedGoogle Scholar
  40. 40.
    Thompson, J.P., Granoff, A., and Willis, D.B. (1986) Proc. Natl. Acad. Sci. USA 83, 7688–7692PubMedCrossRefGoogle Scholar
  41. 41.
    Saluz, H.P., Jiricny, J., and Jost, J.P. (1986) Proc. Natl. Acad. Sci. USA 83, 7167–7171PubMedCrossRefGoogle Scholar

Copyright information

© The Humana Press Inc. 1987

Authors and Affiliations

  • Dagmar Knebel
    • 1
  • Klaus-Dieter Langner
    • 1
  • Arnd Hoeveler
    • 1
  • Ursula Lichtenberg
    • 1
  • Bernd Weisshaar
    • 1
  • Doris Renz
    • 1
  • Walter Doerfler
    • 1
  1. 1.Institute of GeneticsUniversity of CologneCologneGermany

Personalised recommendations