Advertisement

Inhibition of Interleukin-2 Synthesis by Infectious Mononucleosis-Associated IgG Blocking Factor

  • Syam K. Sundar
  • Irina Stefanescu
  • José Menezes
Part of the Experimental Biology and Medicine book series (EBAM, volume 15)

Abstract

Sera from patients with Epstein-Barr virus (EBV)-induced infectious mononucleosis (IM) contain an IgG-blocking factor (IM-IgG) which inhibits cell-mediated immunity. Here we summarize evidence showing that the immunosuppressive effects of IM-IgG result from its inhibitory effect on interleukin-2 production.

Keywords

Natural Killer Natural Killer Cell Nasopharyngeal Carcinoma Infectious Mononucleosis Natural Killer Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    J. Menezes et al. in: Viral Mechanisms of Immuno-suppresion (N. Gilmore and M.A. Wainberg, eds), pp. 115–134 (1985).Google Scholar
  2. 2.
    S.K. Sundar et al. in: Proc. IVth Intern. Symp. on Nasopharyngeal Carcinoma: Current Concepts (U. Prasad et al., eds), pp. 293–297 (1983).Google Scholar
  3. 3.
    R.W. Veltri et al. J. Immunol. 127, 320 (1981).PubMedGoogle Scholar
  4. 4.
    S. Gillis et al. J. Immunol. 120, 2027 (1978).PubMedGoogle Scholar
  5. 5.
    We thank the Canadian Medical Research Council and Justine-Lacoste-Beaubien Foundation for financial support.Google Scholar

Copyright information

© The Humana Press Inc. 1987

Authors and Affiliations

  • Syam K. Sundar
    • 1
  • Irina Stefanescu
    • 1
  • José Menezes
    • 1
  1. 1.Laboratory of ImmunovirologyUniversity of Montreal and Ste-Justine HospitalMontrealCanada

Personalised recommendations