Advertisement

Superinfecting Activity of the B95–8 Isolate of Epstein-Barr Virus

  • K. L. Tarr
  • R. Glaser
  • A. W. Dangel
  • T. Takimoto
  • J. Holliday
  • W. Henle
Part of the Experimental Biology and Medicine book series (EBAM, volume 15)

Abstract

The B95–8 isolate of Epstein-Barr virus (EBV) has been characterized as a transforming strain (1). In contrast, the P3HR-1 (HR-1) isolate has been shown to superinfect latently infected cells such as Raji and NC-37 cells (2), Differences in the activities of these strains of EBV have been thought to be, at least in part, due to specific characteristic deletions in the viral genomes (3). A third isolate of EBV, derived from an epithelial (Ad-AH)/epithelial (NPC tumor) hybrid designated NPC-KT has been shown to have both transforming and lytic biological properties (4,5). Recent work in our laboratory has shown that, by using 100x concentrates of culture supernatants, superinfecting activity can be demonstrated for the B95–8 isolate of EBV.

Keywords

Viral Genome Transforming Strain Virus Stock Raji Cell 3The Child 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    G. Miller and M. Lipman, Proc. Natl. Acad. Sci. USA 70, 190 (1973),PubMedCrossRefGoogle Scholar
  2. 2.
    G. Miller, J. Robinson, L. Heston and M. Lipman, Proc. Natl. Acad. Sci. USA 71, 4006 (1974).PubMedCrossRefGoogle Scholar
  3. 3.
    E. Kieff et al., J. Infec. Dis. 146, 506 (1982).CrossRefGoogle Scholar
  4. 4.
    T. Takimoto, H. Ogura, H. Sato, R. Umeda, M. Hatano, J. Natl. Cancer Inst. 74, 57 (1985).PubMedGoogle Scholar
  5. 5.
    H. Sato, T. Takimoto, H. Ogura, T. Tanaka, M. Hatano and R. Glaser, J. Natl. Cancer Inst. 76, 1019 (1986).PubMedGoogle Scholar

Copyright information

© The Humana Press Inc. 1987

Authors and Affiliations

  • K. L. Tarr
    • 1
  • R. Glaser
    • 1
  • A. W. Dangel
    • 1
  • T. Takimoto
    • 2
  • J. Holliday
    • 1
  • W. Henle
    • 3
  1. 1.The Ohio State University College of MedicineColumbusUSA
  2. 2.Kanazawa UniversityJapan
  3. 3.The Children’s Hospital of PhiladelphiaPhiladelphiaUSA

Personalised recommendations