Abstract
Epstein-Barr Virus (EBV) transforms human B lymphocytes so that they grow as continuous cell lines. B lymphocyte lines transformed in vitro by EBV (LCL) and B lymphocyte lines derived from EBV positive and EBV negative Burkitt’s lymphomas (BL) release a 15–25 K growth enhancing supernatant (GE-S) factor(s) which functions similarly to macrophage derived Interleukin-1 (IL-1). GES and purified IL-1 were compared and both enhanced growth of LCL and BL similarly. Preliminary data show growth of Ramos, an EBV negative BL, is not changed by GE-S or 1L-1, whereas growth of EBV-converted Ramos sublines is enhanced by the addition of either. These initial findings suggest that EBV infection induces the development of growth factor sensitivity in lymphoma cells.
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© 1987 The Humana Press Inc.
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Blazar, B.A., Murphy, A.M. (1987). Comparison of Interleukin-1 with Endogenous B-Cell Factors for Effects on Lymphoma Cell Growth After EBV Conversion. In: Levine, P.H., Ablashi, D.V., Nonoyama, M., Pearson, G.R., Glaser, R. (eds) Epstein-Barr Virus and Human Disease. Experimental Biology and Medicine, vol 15. Humana Press. https://doi.org/10.1007/978-1-4612-4590-2_61
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DOI: https://doi.org/10.1007/978-1-4612-4590-2_61
Publisher Name: Humana Press
Print ISBN: 978-1-4612-8940-1
Online ISBN: 978-1-4612-4590-2
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