Comparison of Interleukin-1 with Endogenous B-Cell Factors for Effects on Lymphoma Cell Growth After EBV Conversion

  • B. A. Blazar
  • Ann Marie Murphy
Part of the Experimental Biology and Medicine book series (EBAM, volume 15)


Epstein-Barr Virus (EBV) transforms human B lymphocytes so that they grow as continuous cell lines. B lymphocyte lines transformed in vitro by EBV (LCL) and B lymphocyte lines derived from EBV positive and EBV negative Burkitt’s lymphomas (BL) release a 15–25 K growth enhancing supernatant (GE-S) factor(s) which functions similarly to macrophage derived Interleukin-1 (IL-1). GES and purified IL-1 were compared and both enhanced growth of LCL and BL similarly. Preliminary data show growth of Ramos, an EBV negative BL, is not changed by GE-S or 1L-1, whereas growth of EBV-converted Ramos sublines is enhanced by the addition of either. These initial findings suggest that EBV infection induces the development of growth factor sensitivity in lymphoma cells.


Burkitis Lymphoma Lymphoblastoid Cell Line Lymphocyte Line Virus Transformed Cell Size Exclusion HPLC 
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  1. 1.
    Blazar, B.A., Sutton, L.M. and Strom, M. Cancer Res. 43:4562 (1983).PubMedGoogle Scholar
  2. 2.
    Gordon, J., Ley, S.C., Melamed, N.D., Aman, P. and Hughes Jones, N.C. J. Exp. Med. 159:1554 (1984).PubMedCrossRefGoogle Scholar
  3. 3.
    Blazar, B.A., Sutton, L.M. and Strom, M. Cancer Immunol. Immunother. 22:62 (1986).PubMedCrossRefGoogle Scholar
  4. 4.
    Blazar, B.A., Rodrick, N.L., Sutton, L.M, and Strom, M. Manuscript submitted.Google Scholar
  5. 5.
    Steinitz, M. and Klein, G. Proc. Natl. Acad. Sci. USA 72:3518 (1975).PubMedCrossRefGoogle Scholar
  6. 6.
    Matsushima, K., Kuang, Y.D., Tosato, G., Hopkins, S.J., Oppenheim, D.J. Cellular Immunol. 9:406 (1985).CrossRefGoogle Scholar

Copyright information

© The Humana Press Inc. 1987

Authors and Affiliations

  • B. A. Blazar
    • 1
    • 2
  • Ann Marie Murphy
    • 1
  1. 1.Harvard Medical SchoolBrigham & Womens HospitalBostonUSA
  2. 2.Wellesley CollegeWellesleyUSA

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