A Preliminary Analysis of HLA Studies on Multiple NPC Cases among Siblings from the People’s Republic of China, Hongkong, Singapore and Malaysia
Earlier studies (1,2) have demonstrated an association between nasopharyngeal carcinoma (NPC) and the occurrence of HLA antigens BW46, B17 and A2. In (2), relative risks of NPC for the phenotypic expression of these antigens were estimated as 1.5 for A2, 2.14 for B17 and 1.88 for BW46. These associations suggest that either the presence of these HLA genes themselves or the occurrence of a non-HLA disease susceptibility gene (DSG) closely linked to the HLA A and B loci is associated with an increased risk of NPC.
KeywordsSibling Pair Haplotype Share Queen Elizabeth Hospital Affected Sibling Pair Disease Susceptibility Gene
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