A Preliminary Analysis of HLA Studies on Multiple NPC Cases among Siblings from the People’s Republic of China, Hongkong, Singapore and Malaysia

  • B. McKnight
  • S. T. Lu
  • L. Ju
  • N. E. Day
  • L. Degos
  • V. Lepage
  • S. H. Chan
  • U. Prasad
  • J. H. C. Ho
  • M. J. Simons
  • Y. Zeng
  • G. de-The
Part of the Experimental Biology and Medicine book series (EBAM, volume 15)

Abstract

Earlier studies (1,2) have demonstrated an association between nasopharyngeal carcinoma (NPC) and the occurrence of HLA antigens BW46, B17 and A2. In (2), relative risks of NPC for the phenotypic expression of these antigens were estimated as 1.5 for A2, 2.14 for B17 and 1.88 for BW46. These associations suggest that either the presence of these HLA genes themselves or the occurrence of a non-HLA disease susceptibility gene (DSG) closely linked to the HLA A and B loci is associated with an increased risk of NPC.

Keywords

Malaysia 

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References

  1. (1).
    Simons et al., Natl Cancer Inst Monogr 47:147–51, 1977PubMedGoogle Scholar
  2. (2).
    Chan et al., Int J Cancer 32:171–6, 1983PubMedCrossRefGoogle Scholar
  3. (3).
    Day and Simons, Tissue Antigens 8:109–19, 1976PubMedGoogle Scholar

Copyright information

© The Humana Press Inc. 1987

Authors and Affiliations

  • B. McKnight
    • 1
  • S. T. Lu
    • 2
  • L. Ju
    • 2
  • N. E. Day
    • 1
  • L. Degos
    • 3
  • V. Lepage
    • 3
  • S. H. Chan
    • 4
  • U. Prasad
    • 5
  • J. H. C. Ho
    • 6
  • M. J. Simons
    • 7
  • Y. Zeng
    • 8
  • G. de-The
    • 9
  1. 1.Unit of BiostatisticsIARCLyonFrance
  2. 2.People’s HospitalNanning, Guang-Xi Aut. RegionPRC
  3. 3.INSERM U93Hopital St. LouisParisFrance
  4. 4.Microbiology Dept.National UniversitySingapore
  5. 5.University of MalayaMalaysia
  6. 6.Institute of Radiology and OncologyQueen Elizabeth HospitalKowloonHongkong
  7. 7.Immunogene Typing LabsImmunoresearchMelbourneAustralia
  8. 8.Institute of VirologyAcademy Preventive MedicineBeijingPRC
  9. 9.Faculty of MedicineLyonFrance

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