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Development of a Set of EBV-Specific Antigens with Recombinant Gene Technology for Diagnosis of EBV-Related Malignant or Nonmalignant Diseases

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Epstein-Barr Virus and Human Disease

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 15))

Abstract

Epstein-Barr virus (EBV) serology can be considerably improved when pure defined antigens are used and antibody class specific tests are applied (1, 2). The identification of antigens is possible by series of Western blots and immunoprecipitations (3). In combination with gene mapping data from hybrid-selected translation (3, 4), recombinant DNA technology was used to produce a panel of viral antigens. These antigens were evaluated in antibody class specific tests in their diagnostic significance for infectious mononucleosis, chronic active EBV infection and nasopharyngeal carcinoma (NPC).

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References

  1. Zhu, X.X., Zeng, Y., Wolf, H. Int. J. Cancer 37, 689–691 (1986).

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Author information

Authors and Affiliations

  1. Max von Pettenkofer Institute, Pettenkoferstr. 9a, 8000, Munich 2, Germany

    H. Wolf, M. Motz, R. Kühbeck, W. Jilg & J. Fan

  2. Institute of Virology, Chinese National Academy for Preventive Medicine, Beijing, China

    J. Fan, G. H. Pi & Y. Zeng

Authors
  1. H. Wolf
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  2. M. Motz
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  3. R. Kühbeck
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  4. W. Jilg
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  5. J. Fan
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  6. G. H. Pi
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  7. Y. Zeng
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Editor information

Editors and Affiliations

  1. National Cancer Institute, Bethesda, Maryland, USA

    P. H. Levine  & D. V. Ablashi  & 

  2. Showa University Research Institute, St. Petersburg, Florida, USA

    M. Nonoyama

  3. Georgetown University Medical Center, Washington, D C, USA

    G. R. Pearson

  4. The Ohio State University, Columbus, Ohio, USA

    R. Glaser

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© 1987 The Humana Press Inc.

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Wolf, H. et al. (1987). Development of a Set of EBV-Specific Antigens with Recombinant Gene Technology for Diagnosis of EBV-Related Malignant or Nonmalignant Diseases. In: Levine, P.H., Ablashi, D.V., Nonoyama, M., Pearson, G.R., Glaser, R. (eds) Epstein-Barr Virus and Human Disease. Experimental Biology and Medicine, vol 15. Humana Press. https://doi.org/10.1007/978-1-4612-4590-2_39

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  • DOI: https://doi.org/10.1007/978-1-4612-4590-2_39

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8940-1

  • Online ISBN: 978-1-4612-4590-2

  • eBook Packages: Springer Book Archive

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