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Morbidity of Epstein-Barr Virus Infection in Children

  • W. M. Roberts
  • R. Wotherspoon
  • H. G. Herrod
  • J. Sixbey
Part of the Experimental Biology and Medicine book series (EBAM, volume 15)

Abstract

Primary infections with the Epstein-Barr virus (EBV) commonly occur in childhood. However, the classical combination of fever, pharyngitis, adenopathy and splenomegaly which is characteristic of infectious mononucleosis in adolescents and young adults is rare in children. On occasion complications of EBV infection may be the only presenting manifestations of EBV disease in children (1). We have retrospectively reviewed the case records of 41 children with EBV disease referred either to a university pediatric department or to a children’s oncology center for presumed malignancy. Our findings suggest that EBV may cause prolonged illness, and, in addition, may lead to serious, potentially life threatening complications.

Keywords

Infectious Mononucleosis Viral Meningitis Atypical Lymphocyte Prolonged Illness Potential Life Threatening Complication 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Bibliography

  1. 1.
    Alpert G and Fleisher GR: Complications of infection with Epstein-Barr virus during childhood: a study of children admitted to the hospital. Pediatr Infect Dis 3:304–307, 1984.PubMedCrossRefGoogle Scholar
  2. 2.
    Brandsma J and Miller G: Nucleic acid spot hybridization: Rapid quantitative screening of lymphoid cell lines for Epstein-Barr viral DNA. Proc Natl Acad Sci 77:6851–6855, 1980.PubMedCrossRefGoogle Scholar

Copyright information

© The Humana Press Inc. 1987

Authors and Affiliations

  • W. M. Roberts
    • 1
    • 2
  • R. Wotherspoon
    • 1
    • 2
  • H. G. Herrod
    • 1
    • 2
  • J. Sixbey
    • 1
    • 2
  1. 1.St. Jude Children’s Research HospitalUSA
  2. 2.Department of PediatricsUniversity of Tennessee, MemphisMemphisUSA

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