Presence of Monoclonal and Oligoclonal B-Cell Proliferation in Fatal Infectious Mononucleosis

  • Beda Brichacek
  • Jack Davis
  • David T. Purtilo
Part of the Experimental Biology and Medicine book series (EBAM, volume 15)

Abstract

Epstein-Barr virus (EBV) is the causative agent of infectious mononucleosis (IM) and has been etiologically linked with endemic African Burkitt’s lymphoma, carcinomas originating in Waldeyer’s ring, thymus and B cell lymphomas in immunosuppressed patients. While IM is a polyclonal B cell proliferative disease in organ transplant recipients, polyclonal oligoclonal or monoclonal lymphoproliferative lesions carrying EBV genome can occur. Congenitally immunodeficient males with X-linked lymphoproliferative syndrome (XLP) usually develop fatal IM (FIM), acquired hypogammaglobulinemia or malignant lymphoma (ML) following infection with EBV. We examined immunoglobulin gene rearrangement in necropsy-derived tissue specimens from 7 patients with FIM occurring sporadically and 5 with XLP.

Keywords

Lymphoma 

Copyright information

© The Humana Press Inc. 1987

Authors and Affiliations

  • Beda Brichacek
    • 1
    • 2
  • Jack Davis
    • 1
    • 2
  • David T. Purtilo
    • 1
    • 2
  1. 1.Dept. Pathology & MicrobiologyPediatrics and the Eppley Institute for Research in CancerOmahaUSA
  2. 2.Ingemar Ernberg, Department of Tumor BiologyKarolinska InstituteStockholmSweden

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