Skip to main content
SpringerLink
Log in
Book cover

Relaxing and Contracting Factors pp 267–283Cite as

Endothelium-Derived Relaxing Factor Relaxes Vascular Smooth Muscle by Cyclic GMP-Mediated Effects on Calcium Movements

  • Chapter

Part of the book series: The Endothelium ((TEEN))

Abstract

The relaxant effect both of endothelium-derived relaxing factor (EDRF) and of the nitrovasodilators on vascular smooth muscle is associated with activation of soluble guanylate cyclase (Rapoport et al., 1983b; Busse et al., 1985) and increased intracellular levels of cyclic guanosine monophosphate (cyclic GMP) (Katsuki et al., 1977; Ignarro et al., 1981; Rapoport et al., 1983a; Rapoport and Murad, 1983; Griffith et al., 1985a). How cyclic GMP regulates contraction of smooth muscle has only recently begun to emerge.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aaronson, P. and van Breemen, C.: Effects of sodium gradient manipulation upon cellular calcium, 45Ca fluxes and cellular sodium in the guinea pig taenia coli. J. Physiol. 319:443–461, 1981.

    PubMed  CAS  Google Scholar 

  • Aksoy, M. O. and Murphy, R. A.: Regulation of the Dynamic Properties of Smooth Muscle: Ca++-Stimulated Cross-Bridge Phosphorylation, in Biochemistry of Smooth Muscle vol. 1 (Stephens, N. L., ed.) CRC, Florida, 1983.

    Google Scholar 

  • Berridge, M.J. and Irvine, R. F.: Inositol triphosphate, a novel second messenger in cellular signal transduction. Nature 312: 315–321, 1984.

    Article  PubMed  CAS  Google Scholar 

  • Busse, R., Trogisch, G., and Bassenge, E.: The role of endothelium in the control of vascular tone. Basic Res. Cardiol. 80: 475–490, 1985.

    Article  PubMed  CAS  Google Scholar 

  • Campbell, M. D., Deth, R. C, Payne, R. A., and Honeyman, T. W.: Phosphoinositide hydrolysis is correlated with agonist-induced calcium influx and contraction in the rabbit aorta. Eur. J. Pharmacol. 116: 129–136, 1985.

    Article  PubMed  CAS  Google Scholar 

  • Collins, P., Griffith, T. M., Henderson, A. H., and Lewis, M. J.: Endothelium and calcium flux in rabbit aortic preparations. J. Physiol. (Lond.) 360: 63P, 1984.

    Google Scholar 

  • Collins, P., Griffith, T. M., Henderson, A. H., and Lewis, M. J.: Endothelium and calcium flux in rabbit aortic preparations. Br. J. Pharmacol. 85: 342P, 1985a.

    Google Scholar 

  • Collins, P., Griffith, T. M., Henderson, A. H., and Lewis, M. J.: 8-Bromo-cGMP and calcium flux in arterial smooth muscle. Br. J. Pharmacol. 85: 279P, 1985b.

    Google Scholar 

  • Collins, P., Griffith, T. M., Henderson, A. H., and Lewis, M. J.: Endothelium-derived relaxing factor alters calcium fluxes in rabbit aorta: A cyclic guano-sine monophosphate-mediated effect. J. Physiol. (Lond.) 381: 427–437, 1986.

    CAS  Google Scholar 

  • Collins, P., Chappell, S. P., Griffith, T. M., Lewis, M. J., and Henderson, A. H.: Differences in basal endothelium-derived relaxing factor activity in different artery types. J. Cardiovasc. Pharmacol. 8: 1158–1162, 1986b

    Article  PubMed  CAS  Google Scholar 

  • Gleason, M. M., Ratz, P. H., and Flaim, S. F.: Measurement of calcium influx in tethered rings of rabbit aorta under tension. Am. J. Physiol. 249: H470-H476, 1985.

    PubMed  CAS  Google Scholar 

  • Godfraind, T., Miller, R. C, and Socrates Lima, J.: Selective α 1 - and α2-adrenoceptor agonist-induced contraction and 45Ca fluxes in the rat isolated aorta. Br. J. Pharmacol. 77:597–604, 1982.

    PubMed  CAS  Google Scholar 

  • Godfraind, T., Egleme, C, and Osachie, J. A.: Role of endothelium in the contractile response of rat aorta to α-adrenoceptor agonists. Clin. Sci. 68 (suppl. 10):65S–71S, 1985.

    PubMed  CAS  Google Scholar 

  • Griffith, T. M., Edwards, D. H., Lewis, M. J., Newby, A. C, and Henderson, A. H.: The nature of endothelium-derived relaxant factor. Nature 308: 645–647, 1984.

    Article  PubMed  CAS  Google Scholar 

  • Griffith, T. M., Edwards, D. H., Lewis, M. J., and Henderson, A. H.: Evidence that cyclic guanosine monophosphate (cGMP) mediates endothelium-dependent relaxation. Eur. J. Pharmacol. 112: 195–202, 1985a.

    Article  PubMed  CAS  Google Scholar 

  • Griffith, T. M., Edwards, D. H., Collins, P., Lewis, M. J., and Henderson, A. H.: Endothelium-derived relaxant factor. J. Roy. Coll. Phys. Lond. 19: 74–79, 1985b.

    CAS  Google Scholar 

  • Griffith, T. M., Edwards, D. H., Newby, A. C, Lewis, M. J., and Henderson, A. H.: Production of endothelium-derived relaxant factor (EDRF) is dependent on oxidative phosphorylation and extracellular calcium. Cardiovasc. Res. 20: 7–12, 1986.

    Article  PubMed  CAS  Google Scholar 

  • Haeusler, G. and Thorens, S.: Pharmacology of vasoactive antihypertensives. Blood Vess. 12: 339, 1975.

    Google Scholar 

  • Hashimoto, T., Hirata, M., Itoh, T., Kanmura, R., and Kuriyama, H.: Inositol 1,4,5-trisphosphate activates pharmacomechanical coupling in smooth muscle of the rabbit mesenteric artery. J. Physiol. 370:605–618, 1986.

    PubMed  CAS  Google Scholar 

  • Hathaway, D. R., Konicki, M. V., and Coolican, S. A.: Phosphorylation of myosin light chain kinase from vascular smooth muscle by cAMP- and cGMP-dependent protein kinases. J. Mol. Cell. Cardiol. 17: 841–850,1985.

    Article  PubMed  CAS  Google Scholar 

  • Hester, R. K.: Effects of 2-nicotinamidoethyl nitrate on agonist-sensitive Ca++ release and Ca++ entry in rabbit aorta. J. Pharmacol. Exp. Ther. 233: 100–111, 1985.

    PubMed  CAS  Google Scholar 

  • Hester, R. K., Weiss, G. B., and Fry, W. J.: Differing actions of nitroprusside and D-600 on tension and 45Ca fluxes in canine and renal arteries. J. Pharmacol Exp. Ther. 208: 155–60, 1979.

    PubMed  CAS  Google Scholar 

  • Ignarro, L. J., Lippton, H., Edwards, J. C, Baricos, W. H., Hyman, A. L., Kadowitz, P. J., and Gruetter, C. A.: Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: Evidence for the involvement of S-nitrothiols as active intermediates. J. Pharmacol. Exp. Ther. 218: 739–749, 1981.

    PubMed  CAS  Google Scholar 

  • Itoh, J., Kuriyama, H., and Ueno, H.: Mechanism of the nitroglycerin-induced vasodilatation in vascular smooth muscles of rabbit and pig. J. Physiol. (Lond.) 343: 233–252, 1983.

    CAS  Google Scholar 

  • Johnson, R. M. and Lincoln, T. M.: Effects of nitroprusside, glyceryl trinitrate, and 8-bromo-cyclic GMP on Phosphorylase a formation and myosin light chain phosphorylation in rat aorta. Mol. Pharmacol. 27: 3333–3342,1985.

    Google Scholar 

  • Karaki, H., Hester, R. K., and Weiss, G. B.: Cellular basis of nitroprusside-induced relaxation of graded responses to norepinephrine and potassium in canine renal arteries. Arch. Int. Pharmacodyn. Ther. 245:198–210,1980.

    PubMed  CAS  Google Scholar 

  • Karaki, H., Nakagawa, H., and Urakawa, N.: Comparative effects of verapamil and sodium nitroprusside on contraction and 45Ca uptake in smooth muscle of rabbit aorta, rat aorta and guinea pig taenia coli. Br. J. Pharmacol. 81: 393–400, 1984.

    PubMed  CAS  Google Scholar 

  • Karaki, H., Nakagawa, H., and Urakawa, N.: Age-related changes in the sensitivity to verapamil and nitroprusside of vascular smooth muscle of rabbit aorta. Br. J.Pharmacol. 85: 223–228, 1985.

    PubMed  CAS  Google Scholar 

  • Katsuki, S., Arnold, W., Mittal, C, and Murad, F.: Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine. J. Cyclic Nucleotide Res. 3: 23–25, 1977.

    PubMed  CAS  Google Scholar 

  • Kreye, V. A. W.: Sodium nitroprusside; approaches towards the elucidation of the mode in action. Trends Pharmacol. Sci. 1: 384–388, 1980.

    Article  CAS  Google Scholar 

  • Kreye, V. A. W., Baron, G. D., Luth, J. B., and Schimdt-Gayk, H.: Mode of action of sodium nitroprusside on vascular smooth muscle. Naunyn Schmiedebergs Arch. Pharmacol. 288: 381–402, 1975.

    Article  PubMed  CAS  Google Scholar 

  • Leitjen, P., Cauvin, C, Lodge, N., Saida, K., and van Breeman, C: Ca++ sources mobilised by α1receptor activation in vascular smooth muscle. Clin. Sci. 68:(suppl. 10):47s–50s, 1985.

    Google Scholar 

  • Lincoln, T. M.: Effects of nitroprusside and 8-bromo-cyclic GMP on the contractile activity of the rat aorta. J. Pharmacol. Exp. Ther. 224:100–107, 1983.

    PubMed  CAS  Google Scholar 

  • Long, C. J. and Stone, T. W.: The release of endothelium-dependent relaxant factor is calcium dependent. Br. J. Pharmacol. 84: 152P, 1985a.

    Google Scholar 

  • Long, C. J. and Stone, T. W.: The release of endothelium-derived relaxant factor is calcium dependent. Blood Vess. 22: 205–208, 1985b.

    CAS  Google Scholar 

  • Loutzenhiser, R. and Epstein, M.: Activation mechanism of human renal artery: Effects of KCl, norepinephrine and nitrendipine upon tension development and 45Ca influx. Eur. J. Pharmacol. 106: 47–52, 1985.

    Article  Google Scholar 

  • Matlib, M. A., Dube, G. P., Millard, R. W., Lathrop, D. A., Baik, Y. H., Sakai, K., DiSalvo, J., and Schwartz, A.: Studies on the mode of action of isosorbide dinitrate: A physiological and biochemical approach. Am. Heart J. 110: 204–212, 1985.

    Article  PubMed  CAS  Google Scholar 

  • McNicol, A. and Maclntyre, D. E.: Reversal of agonist-induced phosphoinositide hydrolysis in human platelets by cAMP, cGMP and 1,2-diacylglycerol. Br. J. Pharmacol. 86: 546P, 1986.

    Google Scholar 

  • Meisheri, L. D., Palmer, L. F., and van Breemen, C: The effects of amrinone on contractility, calcium intake and cAMP in smooth muscle. Eur. J. Pharmacol. 61: 159–165, 1980.

    Article  PubMed  CAS  Google Scholar 

  • Meisheri, K. D., Hwang, O., and van Breemen, C: Evidence for two separate Ca++ pathways in smooth muscle plasma lemma. J. Membr. Biol. 59: 19–25, 1981.

    Article  PubMed  CAS  Google Scholar 

  • Mekata, F.: Current spread in the smooth muscle of the rabbit aorta. J. Physiol. (Lond.) 242: 143–155, 1974.

    CAS  Google Scholar 

  • Morgan, J. P. and Morgan, K. G.: Alteration of cytoplasmic ionised calcium levels in smooth muscle by vasodilators in the ferret. J. Physiol. (Lond.) 357: 539–551, 1984.

    CAS  Google Scholar 

  • Nakazawa, M. and Imai, S.: Effect of nitroglycerin on Ca efflux in the coronary artery. Jpn. J. Pharmacol. 31: 621–625, 1981.

    Article  CAS  Google Scholar 

  • Ozaki, H., Shibata, S., Kitano, H., Masumoto, P., and Ishida, Y.: A comparative study of the relaxing effects of nitroprusside and verapamil on human umbilical vessels. Blood Vess. 18: 321–329, 1981.

    CAS  Google Scholar 

  • Popescu, L. M., Panoiu, C, Hinescu, M., and Nutu, O.: The mechanism of cGMP-induced relaxation in vascular smooth muscle. Eur. J. Pharmacol. 107: 393–394, 1985.

    Article  PubMed  CAS  Google Scholar 

  • Rapoport, R. M.: Cyclic guanosine monophosphate inhibition of contraction may be mediated through inhibition of phosphatidylinositol hydrolysis in rat aorta. Circ. Res. 58: 407–410, 1986.

    PubMed  CAS  Google Scholar 

  • Rapoport, R. M. and Murad, F.: Agonist-inducedendothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP. Circ. Res. 52: 351–357, 1983.

    Google Scholar 

  • Rapoport, R. M., Draznin, M. B., and Murad, F.: Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation. Nature 306: 174–176, 1983a.

    Article  PubMed  CAS  Google Scholar 

  • Rapoport, R. M., Draznin, M. B., and Murad, F.: Endothelium-dependent vasodilator- and nitrovasodilator-induced relaxation may be mediated through cyclic GMP formation and cyclic GMP-dependent protein phosphorylation. Trans. Assoc. Am. Physicians 96: 19–30, 1983b.

    PubMed  CAS  Google Scholar 

  • Rapoport, R. M., Schwartz, K., and Murad, F.: Effect of sodium-potassium pump inhibitors and membrane-depolarising agents on sodium nitroprusside-induced relaxation and cyclic guanosine monophosphate accumulation in rat aorta. Circ. Res. 57: 164–170, 1985.

    PubMed  CAS  Google Scholar 

  • Ratz, P. H., Gleason, M. M., and Flaim, S. F.: Acetylcholine relaxes norepinephrine-contracted rabbit thoracic aorta by inhibiting calcium influx and release. Fed. Proc. 43: 837, 1985.

    Google Scholar 

  • Takai, Y., Karbuchi, K., Matsubara, T., and Mishiyuka, Y.: Inhibitory action of guanosine 3′, 5′-monophosphate on thrombin-induced phosphatidylino-sitol turnover and protein phosphorylation in human platelets. Biochem. Biophys. Res. Comm. 101: 61–67, 1981.

    Article  PubMed  CAS  Google Scholar 

  • van Breemen, C, Aaronson, P. I., Cauvin, C. A., Loutzenhiser, R. D., Mangel, A. W., and Saida, K.: The Calcium Cycle in Arterial Smooth Muscle, in Calcium Blockers (Flaim, S. F. and Zelis, R., eds.) Urban and Schwarzenberg, Baltimore, Munich, 1982.

    Google Scholar 

  • Yamamoto, H. and van Breemen, C.: Inositol-1,4,5-triphosphate releases calcium from skinned cultured smooth muscle cells. Biochem. Biophys. Res. Comm. 130: 270–274, 1985.

    Article  PubMed  CAS  Google Scholar 

  • Zsoter, T. T., Henein, N. F., and Wolchinsky, C: The effect of sodium nitro-prusside on the uptake of 45Ca from rabbit and rat vessels. Eur. J. Pharmacol. 45: 7–12, 1977.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. P. Collins
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. J. Lewis
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. H. Henderson
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Physiology and Biophysics, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA

    Paul M. Vanhoutte

Rights and permissions

Reprints and permissions

Copyright information

© 1988 The Humana Press Inc.

About this chapter

Cite this chapter

Collins, P., Lewis, M.J., Henderson, A.H. (1988). Endothelium-Derived Relaxing Factor Relaxes Vascular Smooth Muscle by Cyclic GMP-Mediated Effects on Calcium Movements. In: Vanhoutte, P.M. (eds) Relaxing and Contracting Factors. The Endothelium. Humana Press. https://doi.org/10.1007/978-1-4612-4588-9_13

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-4588-9_13

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8939-5

  • Online ISBN: 978-1-4612-4588-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation