Modulation of Benzopyrene Dependent Mutagenesis and Xanthine Oxidase Activity by Copper Complexes
Chemical induced murine skin carcinogenesis can be operationally separated into sequential stages. Murine skin tumors can be experimentally produced by a single topical application of a subthreshold dose of carcinogen (initiation) if followed by repetitive treatments with nontumorigenic tumor promoting agents (promotion). Initiation is thought to encompass those events that damage or modify DNA; whereas promotion includes those processes facilitating the expression of the latent effects of initiation. The superoxide dismutase (SOD) biomimetic Cu(II) (3,5-diisopropylsalicylate)2 (CuDIPS) has been reported to inhibit both the initiation1,2 and promotion stages2,3 of murine skin multistage carcinogenesis. The mechanism(s) by which CuDIPS inhibits initiation and promotion are speculative, and are the subject of this article.
KeywordsXanthine Oxidase Xanthine Oxidase Activity Xanthine Dehydrogenase Murine Skin Chemopreventive Property
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