Anticancer Effects of Cu(II)(3,5-Diisopropylsalicylate)2in Mice Inoculated Intramuscularly with Ehrlich Ascites Carcinoma Cells
In 1979, Oberley and Buettner published a review1 which suggested that all neoplastic cells were deficient in total superoxide dismutase (SOD) activity. To determine whether or not Cu-Zn SOD had an anticancer effect, Oberley and Leuthauser injected mi ce wi th a single dose of this enzyme one hour after they implanted Sarcoma 180 tumor cells in the hind limb of CF1 mice and measured average leg diameter versus time after implantation. In animals treated with saline, tumor growth was unimpeded.2 Animals treated with Cu-Zn SOD showed a reduction in tumor growth. Animals treated with Cu-Zn SOD also showed a slight increase in survival in comparison to those treated only with saline-vehicle.
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