Anticancer Effects of Cu(II)(3,5-Diisopropylsalicylate)2in Mice Inoculated Intramuscularly with Ehrlich Ascites Carcinoma Cells

  • Scott L. Kasemeier
  • Hamid Salari
  • John R. J. Sorenson
Part of the Experimental Biology and Medicine book series (EBAM, volume 16)


In 1979, Oberley and Buettner published a review1 which suggested that all neoplastic cells were deficient in total superoxide dismutase (SOD) activity. To determine whether or not Cu-Zn SOD had an anticancer effect, Oberley and Leuthauser injected mi ce wi th a single dose of this enzyme one hour after they implanted Sarcoma 180 tumor cells in the hind limb of CF1 mice and measured average leg diameter versus time after implantation. In animals treated with saline, tumor growth was unimpeded.2 Animals treated with Cu-Zn SOD showed a reduction in tumor growth. Animals treated with Cu-Zn SOD also showed a slight increase in survival in comparison to those treated only with saline-vehicle.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Oberley, LW; Buettner, GR. Cancer Res. 1979, 39, 1141.PubMedGoogle Scholar
  2. 2.
    Oberley, LW; Leuthauser, SWHC; Buettner, GR; Sorenson, JRJ; Oberley, TD; Bize, IB. In: Pathology of Oxygen, Academic Press; New York NY, 1982; p 207.Google Scholar
  3. 3.
    DeAlvare, LR; Goda, K; Kimura T. Biochen. Biophys. Res. Comm. 1976, 69, 687.Google Scholar
  4. 4.
    Brigelius, R; Spottl, R; Bors, W; Lengfelder, E; Saran, M; Weser, U. Febs Lett. 1974, 47, 72.PubMedCrossRefGoogle Scholar
  5. 5.
    Leuthauser, SWHC. Antitumor activities of superoxide dismutase and copper coordination compounds (Dissertation #8012387); University Microfilms International; Ann Arbor MI, 1979.Google Scholar
  6. 6.
    Leuthauser, SWC; Oberley, LW; Oberley, TD; Sorenson, JRJ; Ramakrishna, K. J. Nat. Cancer Inst. 1981, 66, 1077.Google Scholar
  7. 7.
    Sorenson, JRJ; Oberley, LW; Oberley, TD; Leuthauser, SWC; Ramakrishna, K; Vernino, L; Kishore, V. In: Trace Subst. Environ. Health--XVI; University of Missouri; Columbia MO, 1982; p 362.Google Scholar
  8. 8.
    Sahu, SK. Effects of dexamethasone on neuroblastoma cell differentiation, superoxide dismutase activity, and the possible role of negative oxygen ion on cell differentiation (Dissertation #8012417); University Microfilms International; Ann Arbor MI, 1979.Google Scholar
  9. 9.
    Kensler, TW; Trush, MA. Biochen. Pharmacol. 1983, 32, 3485.CrossRefGoogle Scholar
  10. 10.
    Solanki, V; Yotti, L; Logani, MK; Slaga, TJ. Carcinogenesis 1984, 5, 129.PubMedCrossRefGoogle Scholar
  11. 11.
    Wattenberg, LW. Cancer Res. 1985, 45, 1.PubMedCrossRefGoogle Scholar
  12. 12.
    Cerutti, PA. Science 1985, 227, 375.PubMedCrossRefGoogle Scholar
  13. 13.
    Copeland, ES. Cancer Res. 1986, 46, 5451.PubMedGoogle Scholar

Copyright information

© The Humana Press Inc. 1987

Authors and Affiliations

  • Scott L. Kasemeier
    • 1
  • Hamid Salari
    • 1
  • John R. J. Sorenson
    • 1
  1. 1.Department of Biopharmaceutical Sciences, College of PharmacyUniversity of Arkansas for Medical SciencesLittle RockUSA

Personalised recommendations