Modulation of Lymphocyte Function by Copper and Thiols

  • Peter E. Lipsky
Part of the Experimental Biology and Medicine book series (EBAM, volume 16)


D-Penicillamine is effective in the treatment of rheumatoid arthritis. Moreover, D-penicillamine can modify the disease process as evidenced by the capacity to decrease acute phase reactants1. Despite this well-documented evidence of clinical efficacy, the mechanism by which D-penicillamine achieves this therapeutic result in rheumatoid arthritis remains unknown.


Rheumatoid Arthritis Angiotensin Converting Enzyme Inhibitor Lymphocyte Function Natural Killer Cell Function Free Sulfhydryl Group 
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Copyright information

© The Humana Press Inc. 1987

Authors and Affiliations

  • Peter E. Lipsky
    • 1
    • 2
  1. 1.Harold C. Simmons Arthritis Research CenterDallasUSA
  2. 2.Department of Internal MedicineUTHSCD Southwestern Medical SchoolDallasUSA

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