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Pharmacology and Biochemistry of the 5-HT2 Receptor

  • Chapter
The Serotonin Receptors

Part of the book series: The Receptors ((REC))

Abstract

Over the past several years, our understanding of the physiological roles of serotonin has advanced considerably. This increased understanding is in large part a result of the discovery and characterization of multiple binding sites for serotonin, both centrally and peripherally. (In this chapter, the term binding site includes the more rigorously defined concept of a receptor. This question is pursued in greater detail elsewhere in this volume.) The data supporting the existence of these binding sites have been provided by radioligand binding as well as functional studies. Thus, serotonin binding sites are now classified as being of the 5-HT1, 5-HT2, or 5-HT3 type (Bradley et al., 1986). Of these binding sites, the 5-HT2 receptor is best characterized with respect to function. In the periphery, serotonin-induced vascular contraction is mediated by 5-HT2 receptor activation (Houston and Vanhoutte, 1986). Centrally, 5-HT2 receptor activation mediates in part the “serotonin behavioral syndrome” (Leysen, 1985), and is the common site of action of indolealkylamine and phenylalkylamine hallucinogenic agents (Shannon et al., 1984; Glennon et al., 1984; Rasmussen and Aghajanian, 1986; Rasmussen et al., 1986; Lvon et al., 1988; Titeler et al., 1988).

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Authors
  1. Robert A. Lyon
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  2. Milt Titeler
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Editors and Affiliations

  1. Department of Pharmacology and Psychiatry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

    Elaine Sanders-Bush

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Lyon, R.A., Titeler, M. (1988). Pharmacology and Biochemistry of the 5-HT2 Receptor. In: Sanders-Bush, E. (eds) The Serotonin Receptors. The Receptors. Humana Press. https://doi.org/10.1007/978-1-4612-4560-5_3

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  • DOI: https://doi.org/10.1007/978-1-4612-4560-5_3

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8912-8

  • Online ISBN: 978-1-4612-4560-5

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