Abstract
Hypersensitivity pneumonitis (HP) or extrinsic allergic alveolitis (British terminology) is defined as a pulmonary illness caused by an immunologic reaction to a variety of inhaled environmental antigens that involves the periphery of the lung.1 The affected subject acquires an abnormal sensitivity or heightened reactivity to the inciting agent, resulting in an inflammatory host response located primarily in the alveolar-air exchange portion of the lung rather than in the conducting airways seen in asthma. The distinction is important, for certain types of asthma, notably extrinsic, IgE-mediated allergic asthma, is also a form of hypersensitivity lung disease often associated with airborne organic antigens.2
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Schatz M, Patterson R: Hypersensitivity pneumonitis—general considerations. Clin Rev Allergy 1983;1:451–467.
Dickie HA, Rankin J: Farmer’s lung: An acute granulomatous interstitial pneumonitis occurring in agricultural workers. J Am Med Assoc 1958;167:1069–1076.
Pepys J: Hypersensitivity disease of the lungs due to fungi and organic dusts. Monogr Allergy 1969;4:69–131.
Licorish KA: Hypersensitivity pneumonitis—economic and legal aspects. Clin Rev Allergy 1983;1:487–496.
Schlueter DP: Response of the lung to inhaled antigens. Am J Med 1976;57:476.
Salvaggio JE: Hypersensitivity pneumonitis, Robert A. Cooke Memorial Lecture. J Allergy Clin Immunol 1987;79:558–570.
Emanuel DA, Wenzel RJ, Bowerman CI, et al: Farmer’s lung: Clinical, pathologic and immunologic study of twenty-four patients. Am J Med 1964;37:392.
Schlueter DP: Evnrionmental challenge. J Allergy Clin Immunol in press.
Ganier M, Lieberman P, Fink JN, et al: Humidifier lung—an outbreak in office workers. Chest 1980;77:183.
29C.F.R. S1910.1200, 1985.
Mahian F.W., Stiroff RS, Partridge LJ Jr (eds): Occupational health guidelines for clinical hazards. DHHS (NIOSH) Publication no. 81–123.
Sax NI: Dangerous Properties of Industrial Materials (ed. 6) NY, Van Nostrand Reinhold Co., 1984.
Guidelines for bronchial inhalation challenges with pharmacologic and antigenic agents. ATS News, April 11, 1980.
Rosoff AJ: Informed Consent. Rockville, MD, Aspen Systems Corporation, 1981, pp 33–63.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag New York Inc.
About this chapter
Cite this chapter
Schlueter, D.P., Mathai, G., Klein, D. (1989). Hypersensitivity Lung Disease and Challenge Testing. In: Vevaina, J.R., Bone, R.C., Kassoff, E. (eds) Legal Aspects of Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4534-6_30
Download citation
DOI: https://doi.org/10.1007/978-1-4612-4534-6_30
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4612-8867-1
Online ISBN: 978-1-4612-4534-6
eBook Packages: Springer Book Archive