Regulation of Nicotinic Acetylcholine Receptors by Protein Phosphorylation

  • Kathryn Miles
  • Richard L. Huganir
Part of the Molecular Neurobiology · 1988 · book series (MN)


Neurotransmitter receptors and ion channels play a critical role in the transduction of signals at chemical synapses. The modulation of neurotransmitter receptor and ion channel function by protein phosphorylation is one of the major regulatory mechanisms in the control of synaptic transmission. The nicotinic acetylcholine receptor (nAcChR) has provided an excellent model system in which to study the modulation of neurotransmitter receptors and ion channels by protein phosphorylation since the structure and function of this receptor have been so extensively characterized.

In this article, the structure of the nAcChR from the electric organ of electric fish, skeletal muscle, and the central and peripheral nervous system will be briefly reviewed. Emphasis will be placed on the regulation of the phosphorylation of nAcChR by second messengers and by neurotransmitters and hormones. In addition, recent studies on the functional modulation of nicotinic receptors by protein phosphorylation will be reviewed.

Index Entries

cAMP-dependent protein kinase desensitization, ion channels neuropeptides neurotransmitter receptor protein kinase protein kinase C receptor-receptor interactions second messengers tyrosine kinase 


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Copyright information

© The Humana Press Inc. 1989

Authors and Affiliations

  • Kathryn Miles
    • 1
  • Richard L. Huganir
    • 2
  1. 1.The Laboratory of Molecular and Cellular NeuroscienceThe Rockefeller UniversityNew YorkUSA
  2. 2.Howard Hughes Medical Institute, Department of NeuroscienceThe Johns Hopkins University School of MedicineBaltimoreUSA

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