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Vitamin B-6 and B-1 Status during Hormone Therapy of Gynecological Cancer

  • H.-A. Ladner
  • R. M. Salkeld
Part of the Experimental Biology and Medicine book series (EBAM, volume 23)

Summary

The vitamin B-6 status (α-EGOT, PLP in erythrocytes) is impaired in patients with gynecological cancer (cervix uteri, endometrium, ovary and breast), mainly in patients with stage II and III uterine and ovarian carcinomas. We compared the occurrence of 3 important prognostic factors, undifferentiated malignant tumor patients with oestrogen-progesterone-poor receptor status, tumor grading, ploidy status and the epidermal growth factor (EGF) in these patients with the vitamin B-6 status before the beginning of therapy. We found that the low PLP values before treatment were also a prognostic factor for poor survival or the occurrence of distant metastases. Similar to our findings about the lack of influence of chemotherapy on vitamin B-6 and B-1 metabolism, we also found no changes in the vitamin B-6 and B-1 values, (EGOT, PLP and ETK) in 39 patients with gynecological carcinoma during hormone therapy. Only tumor progression caused the vitamin B-6 deficiency in these female tumor patients.

Keywords

Epidermal Growth Factor Receptor Hormone Therapy Ovarian Carcinoma Gynecological Cancer Cervix Uterus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Humana Press Inc. 1990

Authors and Affiliations

  • H.-A. Ladner
    • 1
  • R. M. Salkeld
    • 2
  1. 1.Department of RadiologyUniversity Gynecology ClinicFreiburgFederal Republic of Germany
  2. 2.Section of Clinical Nutrition ResearchF. Hoffmann-La Roche LtdSwitzerland

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