Synthesis of Fatty Acid Ethyl Esters by Brain Membranes

  • Teng-nan Lin
  • Grace Y. Sun
Part of the Experimental Biology and Medicine book series (EBAM, volume 21)


It is long known that chronic ethanol ingestion could result in the development of fatty liver as well as alterations of lipids in other body organs (see review by Lieber, 10). The biochemical mechanism underlying the alcohol-induced lipid changes is not yet clearly understood. However, it is realized that some of the effects may be due to an alteration of the membrane enzymes involved in metabolism of the lipids (see review by Sun and Sun, 17). Nevertheless, ethanol can also undergo a number of oxidative and non-oxidative metabolisms within the cellular system. Among the non-oxidative pathways, ethanol is shown to participate in the biosynthesis of phosphatidylethanol (2) and fatty acid ethyl esters (FAEE) (6). This form of ethanol metabolism has not been explored sufficiently and may contribute to some of the tissue damage which could not be otherwise explained by other form of ethanol metabolism. The aim of this paper, however, is concerning mainly with the latter aspect of ethanol metabolism, i.e. the biosynthesis of FAEE by brain membranes.


Fatty Acid Ester Specific Radioactivity Fatty Acid Ethyl Ester Brain Membrane Ethanol Metabolism 
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Copyright information

© The Humana Press Inc. 1989

Authors and Affiliations

  • Teng-nan Lin
    • 1
  • Grace Y. Sun
    • 1
  1. 1.Sinclair Comparative Medicine Research Farm and Department of BiochemistryUniversity of MissouriColumbiaUSA

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