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Serotonergic Mechanisms in Alcohol Intake

  • David T. Wong
  • James M. Murphy
Chapter
Part of the Experimental Biology and Medicine book series (EBAM, volume 21)

Abstract

Based primarily on animal studies, pharmacological manipulation of brain serotonin (5-hydroxytryptamine, 5HT) neurons has become recognized recently as a potentially important therapeutic approach for the treatment of alcoholism (1,13,38). Two general lines of evidence have implied an inverse relationship between the functioning of the brain 5HT neurotransmitter systems and alcohol drinking behavior: (a) Pharmacological manipulations that increase 5HT functioning cause a reversal of the preference for ethanol and a decrease in alcohol consumption (14,29), and (b) rats and mice that exhibit a high preference for alcohol have a lower content of 5HT and 5-hydroxindoleacetic acid (5HIAA), the primary 5HT metabolite, in several brain regions compared with alcohol-non-preferring animals (28,50 and Lumeng, this volume). In agreement with these findings, some pharmacological manipulations shown to be effective in animal studies have been tested and proven efficacious in decreasing alcohol consumption in humans (1,13,14,36,37), and it has been observed that patients with a history of alcoholism have a lower content of 5HIAA in cerebrospinal fluid (3), lower blood and platelet content of 5HT (4) and a decreased uptake of 5HT into platelets (22).

Keywords

Alcohol Intake Uptake Inhibitor Pharmacological Manipulation Reduce Alcohol Consumption Serotonergic Mechanism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Humana Press Inc. 1989

Authors and Affiliations

  • David T. Wong
    • 1
  • James M. Murphy
    • 2
  1. 1.Lilly Research LaboratoriesEli Lilly and Company Lilly Corporate CenterIndianapolisUSA
  2. 2.The Institute of Psychiatric ResearchIndiana University School of MedicineIndianapolisUSA

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