Abstract
Although studies of the regulation of EBV gene expression focusing on analysis of promoter action in vitro have gained momentum recently, identification of specific regulatory factors that may interact by binding to the promoter regulatory sequences have lagged in EBV systems. Here we summarize the main points of new studies that are the first to detect proteins binding to a key EBV promoter. We selected for our initial studies the presumptive promoter for the gene encoding the EBV nuclear antigen-2 (EBNA-2) (1). We selected this promoter because of the probable importance of the gene product as a contributor to EBV cell transformation (2) and because of our work showing that the function of this promoter is down-regulated by the phorbol ester, TPA (3).
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© 1989 The Humana Press Inc.
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Lin, JC., Kenney, S., Pagano, J.S. (1989). Detection of Proteins Binding to the EBV EBNA-2 Promoter. In: Ablashi, D.V., Faggioni, A., Krueger, G.R.F., Pagano, J.S., Pearson, G.R. (eds) Epstein-Barr Virus and Human Disease • 1988. Experimental Biology and Medicine, vol 20. Humana Press. https://doi.org/10.1007/978-1-4612-4508-7_14
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DOI: https://doi.org/10.1007/978-1-4612-4508-7_14
Publisher Name: Humana Press
Print ISBN: 978-1-4612-8852-7
Online ISBN: 978-1-4612-4508-7
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