Abstract
Lymphotropism has long been thought to be the central feature in the biology of Epstein Barr virus. Recent observations give a new view. EBV enters the human body via the oral route and shows primary replication predominantly in the tonsils. From there the virus is spread throughout the body via lymphoid cells. We have to assume that a widespread spectrum of cells, including the epithelial lineage becomes latently infected. The immune system controls the excessive proliferation of EBV-genome positive peripheral B-lymphocytes, the persistent production of EBV from such lymphocytes and also from other cell types of the body. Saliva remains a lifelong source of EBV, however.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
A. Sauerbrei et al., Laryng. Rhinol. Otol. 62, 170 (1983).
S. Modrow and H. Wolf, PNAS USA 3, 5703 (1986).
S. Modrow et al., Second International Symposium on EBV and Associated Malignant Diseases in St. Petersburg 1986
published in EBV in Human Disease. P.H. Levine, D.V. Ablashi et al., Eds. (Humana Press Inc., 1987), p.407.
A. Hatzubai et al., Int.J.Cancer 40, 358 (1987).
D.T. Rowe et al., EMBOJ 5/10, 2599 (1986).
A.B. Rickinson et al., in EBV in Human Disease. P.H. Levine, D.V. Ablashi et al., Eds. (Humana Press Inc., 1987), p. 335.
W. Jilg et al., in Lymphocytes in immunotherapy of cancer. P. Koldovsky et al., Eds. (Springer Verlag, in press), p. 66.
A. Antonopoulus et al., this issue.
H. Wolf et al., J. Virol. 51, 795 (1984).
J. Greenspan et al., New Engl. J. Med. 313, 1564 (1985).
J.W. Sixbev et al., Lancet, 1122 (15.11.1986).
J. Becker et al., this issue.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 The Humana Press Inc.
About this chapter
Cite this chapter
Wolf, H., Jilg, W., Markert, C., Modrow, S., Zietz, C., Wilmes, E. (1989). The Role of Differentially Expressed EB-Viral and Cellular Genes for Development of Virus-Related Tumors and Possibilities of the Control of These Diseases. In: Ablashi, D.V., Faggioni, A., Krueger, G.R.F., Pagano, J.S., Pearson, G.R. (eds) Epstein-Barr Virus and Human Disease • 1988. Experimental Biology and Medicine, vol 20. Humana Press. https://doi.org/10.1007/978-1-4612-4508-7_13
Download citation
DOI: https://doi.org/10.1007/978-1-4612-4508-7_13
Publisher Name: Humana Press
Print ISBN: 978-1-4612-8852-7
Online ISBN: 978-1-4612-4508-7
eBook Packages: Springer Book Archive