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The Role of Adenosine in Respiratory Physiology

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Adenosine and Adenosine Receptors

Part of the book series: The Receptors ((REC))

Abstract

Adenosine is a purine nucleoside, derived predominantly from the cleavage of 5’adenosine monophosphate (AMP) by 5’nucleotidase (Arch and Newsholme, 1978). The nucleoside subserves both intraand extracellular functions, the latter being effected through specific purine receptors. Two types of extracellular purine receptors have been described: A1 and A2, which can, respectively, inhibit and stimulate adenylate cyclase, modifying intracellular levels of the second messenger cyclic 3’,5’-adenosine monophosphate (Londos and Wolff, 1977; Londos, et al., 1980). More recently, however, these receptors have been defined in terms of their agonist pharmacology (Hamprecht and Van Calker, 1985).

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Authors
  1. Timothy L. Griffiths
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  2. Stephen T. Holgate
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  1. Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Illinois, USA

    Michael Williams

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Griffiths, T.L., Holgate, S.T. (1990). The Role of Adenosine in Respiratory Physiology. In: Williams, M. (eds) Adenosine and Adenosine Receptors. The Receptors. Humana Press. https://doi.org/10.1007/978-1-4612-4504-9_10

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  • DOI: https://doi.org/10.1007/978-1-4612-4504-9_10

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