The Role of Adenosine in Respiratory Physiology

  • Timothy L. Griffiths
  • Stephen T. Holgate
Part of the The Receptors book series (REC)


Adenosine is a purine nucleoside, derived predominantly from the cleavage of 5’adenosine monophosphate (AMP) by 5’nucleotidase (Arch and Newsholme, 1978). The nucleoside subserves both intraand extracellular functions, the latter being effected through specific purine receptors. Two types of extracellular purine receptors have been described: A1 and A2, which can, respectively, inhibit and stimulate adenylate cyclase, modifying intracellular levels of the second messenger cyclic 3’,5’-adenosine monophosphate (Londos and Wolff, 1977; Londos, et al., 1980). More recently, however, these receptors have been defined in terms of their agonist pharmacology (Hamprecht and Van Calker, 1985).


Mast Cell Adenosine Receptor Histamine Release Carotid Body Sodium Cromoglycate 
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© The Humana Press Inc. 1990

Authors and Affiliations

  • Timothy L. Griffiths
  • Stephen T. Holgate

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