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Adenosine Receptors

An Historical Perspective
  • Michael Williams
Part of the The Receptors book series (REC)

Abstract

It is now 60 years since Drury and Szent-Györgyi (1929) found that adenosine produced profound hypotension and bradycardia as well as affecting kidney function in mammals. At a time when the thiazide diuretics, β-adrenergic receptor antagonists, and angiotensin converting enzyme (ACE) inhibitors were unknown, the potential of the nucleoside as an antihypertensive agent was attractive, and con sequently, adenosine was rapidly evaluated in man (Honey et al., 1930; Jezer et al., 1933; Drury, 1936) with disappointing results because of the lability of the natural nucleoside. Accordingly, the purine was felt to have limited usefulness as an antihypertensive agent, and it was not until the 1950s that the effects of adenosine on mammalian cellular function were again evaluated (Green and Stoner, 1950; Feldberg and Sherwood, 1953; Winbury et al.,1953; Wolf and Berne, 1956). The hypotensive actions of adenosine were reconfirmed, as was the ability of the purine to modulate pulmonary and CNS function.

Keywords

Adenosine Receptor Adenosine Deaminase Adenosine Antagonist Purine Receptor Adenosine Receptor Activation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© The Humana Press Inc. 1990

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  • Michael Williams

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