Receptor-Mediated Endocytosis and Intracellular Processing of Insulin: Ultrastructural and Biochemical Evidence for Cell-Specific Heterogeneity and Distinction from Nonhormonal Ligands

  • Robert M. Smith
  • Leonard Jarett


The purpose of this review is to present biochemical and ultrastructural evidence which demonstrate that differences exist between the binding, internalization and intracellular processing of insulin and other types of ligands such as LDL and alpha-2-macroglobulin. In addition, other data will show that there is substantial cell-specific heterogeneity among different cell types in the processing of the insulin-receptor complex.


Insulin Receptor Insulin Binding Liver Plasma Membrane Occupied Receptor Adipocyte Plasma Membrane 
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Copyright information

© Humana Press · Clifton, New Jersey 1989

Authors and Affiliations

  • Robert M. Smith
    • 1
  • Leonard Jarett
    • 1
    • 2
  1. 1.Department of Pathology and Laboratory MedicineUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  2. 2.Department of Pathology and Laboratory MedicineHospital University of PennsylvaniaPhiladelphiaUSA

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