Skip to main content
SpringerLink
Log in

Fatty Involution of Marrow and the Role of Adipose Tissue in Hemopoiesis

  • Chapter
Handbook of the Hemopoietic Microenvironment

Part of the book series: Contemporary Biomedicine ((CB,volume 9))

Abstract

On gross examination, bone marrow may be red or yellow. Red marrow is hemopoietic and contains all cell lines normally considered to be associated with hemopoiesis. It derives its color from heme chromogen of erythrocytes and their pigmented precursors. By contrast, the major cell type in yellow marrow is the adipocyte (Fig. 1) that imparts a yellow color. Hence, yellow marrow is also known as fatty marrow. This marrow is not normally hemopoietic and is considered as a natural experimental model for marrow aplasia.1

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Tavassoli, M. (1978) Aplastic Anemia (Hibino, S., Takaku, R, and Shahidi, N. T., eds.), University of Tokyo Press, Tokyo.

    Google Scholar 

  2. Tavassoli, M. (1980) Blood, Pure and Eloquent (Wintrobe, M. M., ed.), McGraw-Hill, New York.

    Google Scholar 

  3. Neumann, E. (1882) Centr. Med. Wissensch. 20, 321–323.

    Google Scholar 

  4. Askanazy, M. (1927) Handbuch der Speziellen Pathologischen Anatomie und Histobgie (Henke, R and Lubrasch, O., eds.), Springer, Berlin, 1,2,775.

    Google Scholar 

  5. Peabody, R W. (1926) Am. J. Pathol. 2, 487–502.

    PubMed  CAS  Google Scholar 

  6. Oehlbeck, L. W. R, Robscheit-Robbins, F. S., and Whipple, G. H. (1932) J. Exp. Med. 56, 425–448.

    Article  PubMed  CAS  Google Scholar 

  7. Hashimoto, M. (1962) Acta Hematol. 27, 193–216.

    Article  CAS  Google Scholar 

  8. Custer, R. P. and Ahlfeldt, F. E. (1932) J. Lab. Clin. Med. 17, 960–962.

    Google Scholar 

  9. Uchida, M. (1958) J. Kyu. Hem. Soc. 8, 905.

    Google Scholar 

  10. Nagahama, M. (1959) J. Kyu. Hem. Soc. 9, 299,300.

    Google Scholar 

  11. Tateno, K. (1957) J. Kyu. Hem. Soc. 7, 150.

    Google Scholar 

  12. Higuchi, T. (1959) J. Kyu. Hem. Soc. 9, 613.

    Google Scholar 

  13. Huggins, C. B., Blocksom, B. H., and Noonan, W. J. (1936) Am. J. Physiol. 115, 395–401.

    Google Scholar 

  14. Huggins, C. B. and Blocksom, B. H. (1936) J. Exp. Med. 64, 253–274.

    Article  PubMed  CAS  Google Scholar 

  15. Huggins, C. B. and Noonan, W. J. (1936) J. Exp. Med. 64, 275–280.

    Article  PubMed  CAS  Google Scholar 

  16. Weiss, L. P. and Wislocki, G. B. (1956) Anat. Rec. 126, 143–163.

    Article  PubMed  CAS  Google Scholar 

  17. Tavassoli, M. and Yoffey, J. M. (1983) Bone Marrow: Structure and Function Liss, New York.

    Google Scholar 

  18. Frassoni, R, Testa, N. G., and Lord, B. I. (1982) Cell Tissue Kinet. 15, 447–455.

    PubMed  CAS  Google Scholar 

  19. Lord, B. I., Testa, N. G., and Hendry, J. H. (1975) Blood 45, 65–72.

    Google Scholar 

  20. Lord, B. I., and Hendry, J. H. (1972) Br. J. Radiol. 45, 110–115.

    Article  PubMed  CAS  Google Scholar 

  21. Lambersten, R. H. and Weiss, L. (1984) Blood 63, 287–297.

    Google Scholar 

  22. Van Dyke, D. (1967) Clin. Orthop. 52, 37–51.

    Article  PubMed  Google Scholar 

  23. Patt, H. M. and Maloney, M. A. (1970) Hemopoietic Cellular Proliferation (Stohlman, F, ed.), Grune and Stratton, New York, pp. 55–66.

    Google Scholar 

  24. Gong, J. K. (1978) Science 199, 1443,1444.

    Article  PubMed  CAS  Google Scholar 

  25. Tavassoli, M. (1982) Blood 60, 1059–1067.

    PubMed  CAS  Google Scholar 

  26. Little, K. (1969) Gerontobgia. 15, 155–170.

    Article  CAS  Google Scholar 

  27. Petrakis, N. L. (1966) Am. J. Phys. Anthrop. 25, 119–130.

    Article  PubMed  CAS  Google Scholar 

  28. Hamazato, Y. (1968) J. Kyu. Hem. Soc. 8, 25.

    Google Scholar 

  29. Sheard, A. (1924) Prenicious Anaemia and Aplastic Anaemia, Williams Wood, New York.

    Google Scholar 

  30. Knospe, W. H., Rayudu, V. M. S., Cardello, M., Friedman, A. M., and Fordham, E. W. (1976) Cancer 37, 1432–1442.

    Article  PubMed  CAS  Google Scholar 

  31. Maniatis, A., Tavassoli, M., and Crosby, W. H. (1971) Blood 37, 581–586.

    PubMed  CAS  Google Scholar 

  32. Tavassoli, M. and Crosby, W. H. (1968) Science 161, 54–56.

    Article  PubMed  CAS  Google Scholar 

  33. Sahebekhtiari, H. A. and Tavassoli, M. (1978) Cell Tissue Res. 192, 437–450.

    PubMed  CAS  Google Scholar 

  34. Sadr, A. M., Cardenas, R, and Tavassoli, M. (1980) Experientia 36, 605,606.

    Article  PubMed  CAS  Google Scholar 

  35. Tavassoli, M. and Khademi, R. (1980) Experientia 36, 1126,1127.

    Article  PubMed  CAS  Google Scholar 

  36. Tavassoli, M. (1984) Long-Term Bone Marrow Culture (Wright, D. G. and Greenberger, J. S., eds.), Liss, New York.

    Google Scholar 

  37. Tavassoli, M. and Crosby, W. H. (1970) Science 169, 291–293.

    Article  PubMed  CAS  Google Scholar 

  38. Maloney, M. A., Flannery, M. L., and Patt, H. M. (1980) Proc. Soc. Exp. Biol. Med. 165, 309–312.

    PubMed  CAS  Google Scholar 

  39. Bigelow, C. L. and Tavassoli, M. (1984) Exp. Hematol. 12, 581–585.

    PubMed  CAS  Google Scholar 

  40. Abercrombie, M. (1967) Cell Differentiation (DeReuck, A. V. S. and Knight, J., eds.), Little, Brown, Boston.

    Google Scholar 

  41. Patt, H. M., Maloney, M. A., and Flannery, M. L. (1982) Exp. Hematol. 10, 738–742.

    PubMed  CAS  Google Scholar 

  42. Tavassoli, M., Maniatis, A., and Crosby, W. H. (1974) Blood 43, 33–38.

    PubMed  CAS  Google Scholar 

  43. Tavassoli, M., Maniatis, A., and Crosby, W. H. (1972) Br. J. Haematol. 23, 707–711.

    Article  PubMed  CAS  Google Scholar 

  44. Tavassoli, M., Watson, L. R., and Khademi, M. R. (1979) Cell Tissue Res. 200, 215–222.

    Article  PubMed  CAS  Google Scholar 

  45. Weiman, D. (1944) Trans. Am. Philos. Soc. 33, 243–350.

    Article  Google Scholar 

  46. Tavassoli, M. (1976) Acta Anat. 94, 65–77.

    Article  PubMed  CAS  Google Scholar 

  47. Bigelow, C. L. and Tavassoli, M. (1984) Acta Anat. 118, 60–64.

    Article  PubMed  CAS  Google Scholar 

  48. Weiss, L. (1965) J. Morphol. 117, 467–538.

    Article  PubMed  CAS  Google Scholar 

  49. Tavassoli, M. (1974) Arch. Pathol. 98, 189–192.

    PubMed  CAS  Google Scholar 

  50. Tavassoli, M. (1978) Scand. J. Haematol. 20, 330–334.

    Article  PubMed  CAS  Google Scholar 

  51. Tavassoli, M., Hanchin, D. N., and Jacob, P. (1977) Scand. J. Haematol. 18, 47–53.

    Article  PubMed  CAS  Google Scholar 

  52. Evans, J. D., Baker, J. M., and Oppenheimer, M. J. (1955) Am. J. Physiol. 181, 504–512.

    PubMed  CAS  Google Scholar 

  53. Evans, J. D. and Oppenheimer, M. J. (1955) Am. J. Physiol. 181, 509–512.

    PubMed  CAS  Google Scholar 

  54. Cohen, P. and Gardner, F. H. (1965) J. Lab. Clin. Med. 65, 88–101.

    PubMed  CAS  Google Scholar 

  55. Krause, R. F. (1943) J. Biol. Chem. 149, 395–505.

    CAS  Google Scholar 

  56. Dietz, A. A. and Steinberg, B. (1953) Arch. Biochem. 45, 1–9.

    Article  PubMed  CAS  Google Scholar 

  57. Lee, M. Y. and Rosse, C. (1979) Anat. Rec. 195, 31–46.

    Article  PubMed  CAS  Google Scholar 

  58. Bathija, A., Davis, S., and Trubowitz, S. (1978) Am. J. Hematol. 5, 315–321.

    Article  PubMed  CAS  Google Scholar 

  59. Lewis, G. M., Efstratiadis, A. A., Mantzos, J. D., and Miras, C. J. (1975) Radiat. Res. 61, 342–349.

    Article  Google Scholar 

  60. Ahlers, I., Ahlersova, E., Sedlakova, A., and Praslicka, M. (1973) Folia. Biol. 19, 130–134.

    CAS  Google Scholar 

  61. Snyder, F. (1965) Nature 206, 733.

    Article  PubMed  CAS  Google Scholar 

  62. Pfleger, R. C. and Snyder, F. (1967) Radiat. Res. 30, 325–328.

    Article  PubMed  CAS  Google Scholar 

  63. Snyder, F. (1966) Radiat Res. 27, 375–383.

    Article  PubMed  CAS  Google Scholar 

  64. Dietz, A. A. and Steinberg, B. (1950) Arch. Biochem. 26, 291–298.

    PubMed  CAS  Google Scholar 

  65. Greenberger, J. S. (1979) In Vitro 15, 823–828.

    Article  PubMed  CAS  Google Scholar 

  66. Tavassoli, M. (1979) Br. J. Haematol. 41, 297–302.

    Article  PubMed  CAS  Google Scholar 

  67. Tavassoli, M. (1978) Exp. Hematol. 6, 257–269.

    PubMed  CAS  Google Scholar 

  68. Tavassoli, M. (1977) Br. J. Haematol. 35, 25–32.

    Article  PubMed  CAS  Google Scholar 

  69. Napolitano, L. (1963) J. Cell Biol. 18, 663–679.

    Article  PubMed  CAS  Google Scholar 

  70. Slavin, B. G. (1972) Int. Rev. Cytol. 33, 297–334.

    Article  PubMed  CAS  Google Scholar 

  71. Tavassoli, M. (1974) Experientia 30, 424,425.

    Article  Google Scholar 

  72. Trubowitz, S. and Bathija, A. (1977) Blood 49, 599–605.

    PubMed  CAS  Google Scholar 

  73. Greenberger, J. S. (1978) Nature 255, 752–754.

    Article  Google Scholar 

  74. Tavassoli, M. (1982) Exp. Cell Res. 137, 55–62.

    Article  PubMed  CAS  Google Scholar 

  75. Bathija, A., Davis, S., and Trubowitz, S. (1979) Am. J. Hematol. 6, 191–198.

    Article  PubMed  CAS  Google Scholar 

  76. Tavassoli, M., Eastlund, D. T., Yam, L. T., Neiman, R. S., and Finkel, H. E. (1976) Scand. J. Haematol. 16, 311–319.

    Article  PubMed  CAS  Google Scholar 

  77. McCuskey, R. S., Meinke, H. A., and Townsend, S. F. (1972) Blood 39, 696–712.

    Google Scholar 

  78. Helweg-Larsen, P., Hoffmeyer, H., Kieler, J., Thaysen, H. E., Thaysen, J. S., Thaysen, P., and Wulff, M. H. (1952) Acta Med. Scand. 274, 170–173.

    Google Scholar 

  79. Kondi, A., McDougall, L., Hoy, H., Mehta, S., and Mliaya, V. (1963) Arch. Dis. Child. 38, 267–275.

    Article  PubMed  CAS  Google Scholar 

  80. Allen, D. W. and Dean, R. F. A. (1965) Trans. R. Soc. Trop. Med. Hyg. 59, 326–341.

    Article  PubMed  CAS  Google Scholar 

  81. Mant, M. J. and Faragher, B. S. (1972) Br. J. Haematol. 23, 737–749.

    Article  PubMed  CAS  Google Scholar 

  82. Tavassoli, M. (1976) Arch. Pathol. Lab. Med. 100, 16–18.

    PubMed  CAS  Google Scholar 

  83. Tavassoli, M. and Takahashi, K. (1982) Am. J. Anat. 164, 91–111.

    Article  PubMed  CAS  Google Scholar 

  84. Hull, D. and Segall, M. M. (1966) Nature 212, 469–472.

    Article  PubMed  CAS  Google Scholar 

  85. Hull, D. (1966) Br. Med. Bull. 22, 92–96.

    PubMed  CAS  Google Scholar 

  86. Napolitano, L. and Fawchett, D. (1958) J. Biophys. Biochem. Cytol. 4, 685–692.

    Article  PubMed  CAS  Google Scholar 

  87. Dexter, T. M., Allen, T. D., and Lajtha, L. G. (1977) J. Cell Physiol. 91, 335–344.

    Article  PubMed  CAS  Google Scholar 

  88. Chase, W. H. (1959) J. Ultrastruct Res. 2, 283–287.

    Article  PubMed  CAS  Google Scholar 

  89. Barnett, R. J. and Ball, E. G. (1960) J. Biophys. Biochem. Cytol. 8, 83–100.

    Article  Google Scholar 

  90. Cushman, S. W. (1970) J. Cell Biol. 46, 326–341.

    Article  PubMed  CAS  Google Scholar 

  91. Gerrity, R. G. (1981) Am. J. Pathol. 103, 181–190.

    PubMed  CAS  Google Scholar 

  92. Zucker-Franklin, D., Grusky, G., and Marcus, A. (1978) Lab. Invest. 38, 620–628.

    PubMed  CAS  Google Scholar 

  93. Touw, I. and Lowenberg, B. (1983) Blood 61, 770–774.

    PubMed  CAS  Google Scholar 

  94. Sakakeeny, M. A. and Greenberger, J. S. (1982) J. Natl. Cancer Inst. 68, 305–317.

    PubMed  CAS  Google Scholar 

  95. Greenberger, J. S., Sakakeeny, M. A., and Parker, L. M. (1979) Exp. Hematol. 7, 135–148.

    PubMed  Google Scholar 

  96. Eastment, C., Denholm, E., Katznelson, I., Arnold, E., and Tso, P. O. P. (1982) Blood 60, 123–135.

    Google Scholar 

  97. Eastment, C. E., Ruscetti, F. W., Denholm, E., Katznelson, I., Arnold, E., and Tso, P. O. P. (1982) Blood 60, 495–502. ai]98 Eastment, C. E. and Ruscetti, F. W. (1982) Blood 60, 999–1006.

    PubMed  CAS  Google Scholar 

  98. Zakaria, E. and Shafrir, E. (1967) Proc. Soc. Exp. Biol. Med. 124, 1265–1268.

    PubMed  CAS  Google Scholar 

  99. Soda, R. and Tavassoli, M. (1983) Int. J. Cell Cloning 1, 79–84.

    Article  PubMed  CAS  Google Scholar 

  100. Takahashi, M. and Tavassoli, M. (1983) J. Ultrastruct. Res. 83, 233–241.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. Mehdi Tavassoli
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Veterans Administration Medical Center, University of Mississippi School of Medicine, Jackson, Mississippi, USA

    Mehdi Tavassoli

Rights and permissions

Reprints and permissions

Copyright information

© 1989 The Humana Press Inc.

About this chapter

Cite this chapter

Tavassoli, M. (1989). Fatty Involution of Marrow and the Role of Adipose Tissue in Hemopoiesis. In: Tavassoli, M. (eds) Handbook of the Hemopoietic Microenvironment. Contemporary Biomedicine, vol 9. Humana Press. https://doi.org/10.1007/978-1-4612-4494-3_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-4494-3_4

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8845-9

  • Online ISBN: 978-1-4612-4494-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation