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Pelvic Inflammatory Disease

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Office Gynecology
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Abstract

Pelvic inflammatory disease (PID) is a general term connoting inflammation caused by an infection in the upper genital tract. It is a disease that has reached epidemic proportions in the 1990s and may include infection of any or all the following: endometrium, myometrium, oviducts, ovaries, uterine serosa, parametrium, or pelvic peritoneum. Pelvic inflammatory disease is inarguably an extremely serious reproductive health problem. Each year, more than 1 million U.S. women experience an episode of PID,1,2 with at least one-fourth of them suffering one or more serious, long-term sequelae.3–5

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References

  1. Rolfs RT, Galaid EL, Zaidi AA. Epidemiology of pelvic inflammatory disease: trends in hospitalizations and office visits, 1979–1988. In: Proceedings of the Centers for Disease Control and National Institutes of Health joint meeting, Pelvic Inflammatory Disease: Prevention, Management, and Research in the 1990s. Bethesda, Md; September 4–5, 1990.

    Google Scholar 

  2. Washington AE, Cates W, Zaidi AA. Hospitalizations for pelvic inflammatory disease: epidemiology and trends in the United States, 1975 to 1982. JAMA. 1984; 251: 2529–2533.

    Article  PubMed  CAS  Google Scholar 

  3. Westrom L. Incidence, prevalence, and trends of acute pelvic inflammatory disease and its consequences in industrialized countries. Am J Obstet Gynecol. 1980; 138: 880–892.

    PubMed  CAS  Google Scholar 

  4. Cates W, Rolfs RT, Aral SO. Sexually transmitted diseases, pelvic inflammatory disease and infertility: an epidemiologic update. Epidemiol Rev. 1990; 12: 199–220.

    PubMed  Google Scholar 

  5. Sweet RL. Pelvic inflammatory disease. In: Sweet RL, Gibbs RS, eds. Infectious Diseases of the Female Genital Tract. Baltimore, Md: Williams & Wilkings; 1990: 241–266.

    Google Scholar 

  6. Washington AE, Katz P. Cost of the payment source for pelvic inflammatory disease: trends and Projections, 1983 through 2000. JAMA. 1991; 266: 2565–2569.

    Article  PubMed  CAS  Google Scholar 

  7. Westrom L, Svensson L, Wolner-Hanssen P, Mardh P-A. Chlamydial and gonococcal infection in a defined population of women. Scand J Infect Dis. 1982; 32 (suppl): 157–162.

    CAS  Google Scholar 

  8. Mardh P-A. An overview of infectious agents in salpingitis: their biology, and recent advances in methods of detection. Am J Obstet Gynecol. 1980; 138: 933–951.

    PubMed  CAS  Google Scholar 

  9. Sweet RL, Draper DL, Hadley WK. Etiology of acute salpingitis: influence of episode number and duration of symptoms. Obstet Gynecol. 1981; 58: 62–68.

    PubMed  CAS  Google Scholar 

  10. Eschenbach DA, Harnisch JP, Holmes KK. Pathogenesis of acute pelvic inflammatory disease: role of contraception and other risk factors. Am J Obstet Gynecol. 1977; 128: 838–850.

    PubMed  CAS  Google Scholar 

  11. Hadley WK, Brooks GF. Microbiology and pathogenesis of acute salpingitis as determined by laparoscopy: what is the appropriate site to sample? Am J Obstet Gynecol. 1980;138:985–989.

    PubMed  Google Scholar 

  12. Eschenbach DA, Buchanan TM, Pollock HM, et al. Polymicrobial etiology of acute pelvic inflammatory disease. N Engl J Med. 1975; 293: 166–172.

    Article  PubMed  CAS  Google Scholar 

  13. Thompson SE, Hager WD, Wong KH, et al. The microbiology and therapy of acute pelvic inflammatory disease in hospitalized patients. Am J Obstet Gynecol. 1980; 136: 179–186.

    PubMed  Google Scholar 

  14. Droegemueller W. Upper genital tract infections. In: Droegemueller W, Herbst AL, Mishell DR Jr., Stenchever MA, eds. Comprehensive Gynecology. St. Louis, Mo: CV Mosby; 1987: 614–642.

    Google Scholar 

  15. Rice PA, Schacter J. Pathogenesis of pelvic inflammatory disease. JAMA. 1991;266:2587–2593.

    Article  PubMed  CAS  Google Scholar 

  16. James AN, Knox JM, Williams RP. Attachment of gonococci to sperm: influence of physical and chemical factors. Br J Vener Dis. 1975; 52: 128–135.

    Google Scholar 

  17. Wolner-Hanssen P, Mardh P-A. In vitro tests of the adherence of Chlamydia trachomatis to human spermatozoa. Fertil Steril. 1984;42:102–107.

    Google Scholar 

  18. Keith LG, Berger GS, Edelman DA, et al. On the causation of pelvic inflammatory disease. Am J Obstet Gynecol. 1984; 149: 215–224.

    PubMed  CAS  Google Scholar 

  19. Patton DL, Haibert SA, Kuo CC, Wang SP, Holmes KK. Host response to primary Chlamydia trachomatis infection of the fallopian tube in pigtailed monkeys. Fertil Steril. 1983; 40: 829–840.

    PubMed  CAS  Google Scholar 

  20. Patton DL, Kuo CC, Wang SP, Haibert SA. Distal obstruction induced by repeated Chlamydia trachomatis salpingeal infections in pig- tailed macaques. J Infect Dis. 1987; 155: 1292–1299.

    Article  CAS  Google Scholar 

  21. Patton DL, Landers DV, Schacter J. Experimental Chlamydia trachomatis salpingitis in mice: initial studies on the characterization of the leukocyte response to chlamydial infection. J Infect Dis. 1989; 159: 1105–1110.

    Article  PubMed  CAS  Google Scholar 

  22. McGeer ZA, Johnson AP, Taylor-Robinson D. Pathogenic mechanisms of Neisseria gonorrhoeae: observations on damage of human fallopian tubes in organ culture by gonococci of colony type 1 or type 4. J Infect Dis. 1981; 143: 413–422.

    Article  Google Scholar 

  23. Gregg CR, Melly MA, Hellerqvist CG, Con- iglio JG, McGee ZA. Toxic activity of purified lipopolysaccharide of Neisseria gonorrhoeae for human fallopian tube mucosa. J Infect Dis. 1981; 143: 432–439.

    Article  PubMed  CAS  Google Scholar 

  24. Melly MA, McGee ZA, Rosenthal RS. Ability of monomeric peptidoglycan fragments from Neisseria gonorrhoeae to damage human fallopian-tube mucosa. J Infect Dis. 1984; 149: 378–386.

    Article  PubMed  CAS  Google Scholar 

  25. Densen P, MacKeen LA, Clark RA. Dissemination of gonococcal infection is associated with delayed stimulation of complement- dependent neurophil Chemotaxis in vitro. Infect Immun. 1982; 80: 78–87.

    Google Scholar 

  26. Bell TA, Holmes KK. Age-specific risks of syphilis, gonorrhea, and hospitalized pelvic inflammatory disease in sexually experienced U.S. women. Sex Transm Dis. 1984;11:291–295.

    Google Scholar 

  27. Wolner-Hanssen P, Eschenbach DA, Paavo- nen J, et al. Decreased risk of symptomatic chlamydial pelvic inflammatory disease associated with oral contraceptive use. JAMA. 1990; 263: 54–59.

    Article  PubMed  CAS  Google Scholar 

  28. Marchbanks PA, Lee NC, Peterson HB. Cigarette smoking as a risk factor for pelvic inflammatory disease. Am J Obstet Gynecol. 1990; 162: 639–644.

    PubMed  CAS  Google Scholar 

  29. Aral SO, Mosher WD, Cates W Jr. Self- reported pelvic inflammatory disease in the United States, 1988. JAMA. 1991;266:2570–2573.

    Article  Google Scholar 

  30. Ledegaard O, Helm P. Pelvic inflammatory disease: the influence of contraceptive, sexual and social life events. Contraception. 1990; 41: 475–483.

    Article  Google Scholar 

  31. Lee NC, Rubin GL, Grimes DA. Measures of sexual behavior and the risk of pelvic inflammatory disease. Obstetrics and Gynecology. 1991; 77: 424–430.

    Google Scholar 

  32. Centers for Disease Control. Condoms for prevention of sexually transmitted diseases. MMWR. 1988; 37: 133–137.

    Google Scholar 

  33. Cromer BA, Heald FP. Pelvic inflammatory disease associated with Neisseria gonorrhoeae and Chlamydia trachomatis: clinical correlates. Sex Transm Dis. 1987; 14: 125–129.

    Article  PubMed  CAS  Google Scholar 

  34. Harrison HR, Costin M, Meder JB, et al. Cervical Chlamydia trachomatis infection in university women: relationship to history, contraception, ectopy, and cervicitis. Am J Obstet Gynecol. 1985; 153: 244–251.

    PubMed  CAS  Google Scholar 

  35. Washington AE, Gove S, Schachter J, Sweet RL. Oral contraceptive, Chlamydia trachomatis infection, and pelvic inflammatory disease: a word of caution about protection. JAMA. 1985; 253: 2246–2250.

    Article  PubMed  CAS  Google Scholar 

  36. Senanayake P, Kramer DG. Contraception and the etiology of pelvic inflammatory disease: new perspectives. Am J Obstet Gynecol. 1980; 138: 852–860.

    PubMed  CAS  Google Scholar 

  37. World Health Organization. Mechanism of Action, Safety and Efficacy of Intrauterine Devices. Geneva, Switzerland: World Health Organization; 1987; Technical report series 753.

    Google Scholar 

  38. Lee NC, Rubin GL, Ory HW, Burkman RT. Type of intrauterine device and the risk of pelvic inflammatory disease. Obstet Gynecol. 1983; 62: 1–6.

    PubMed  CAS  Google Scholar 

  39. Wolner-Hanssen P, Eschenbach DA, Paavo- nen J, et al. Association between vaginal douching and acute pelvic inflammatory disease. JAMA. 1990; 263: 1936–1941.

    Article  PubMed  CAS  Google Scholar 

  40. Marchbanks PA., Lee NC, Peterson HB. Cigarette smoking as a risk factor for pelvic inflammatory disease. Am J Obstet Gynecol. 1990; 162: 639–644.

    PubMed  CAS  Google Scholar 

  41. Sweet RL, Blankfort-Doyle M, Robbie MO, Schachter J. The occurrence of chlamydial and gonococcal salpingitis during the menstrual cycle. JAMA. 1986; 255: 2062–2064.

    Article  PubMed  CAS  Google Scholar 

  42. Jacobson L, Westrom L. Objectivized diagnosis of acute pelvic inflammatory disease: diagnostic and prognostic value of routine laparoscopy. Am J Obstet Gynecol. 1969; 105: 1088–1098.

    PubMed  CAS  Google Scholar 

  43. Hager WD, Eschenbach DA, Spence MR, Sweet RL. Criteria for diagnosis and grading of salpingitis. Obstet Gynecol. 1983; 61: 113–114.

    PubMed  CAS  Google Scholar 

  44. Hadgu A, Westrom L, Brooks CA, Reynolds GH, Thompson SE. Predicting acute pelvic inflammatory disease: a multivariate analysis. Am J Obstet Gynecol. 1986; 155: 954–960.

    PubMed  CAS  Google Scholar 

  45. Paavonen J, Aine R, Teisala K, Heinonen PK, Punnonen R. Comparison of endometrial biopsy and peritoneal fluid cytologic testing with laparoscopy in the diagnosis of acute pelvic inflammatory disease. Am J Obstet Gynecol. 1985; 151: 645–650.

    PubMed  CAS  Google Scholar 

  46. Bongard F, Landers DV, Lewis F. Differential diagnosis of appendicitis and pelvic inflammatory disease: a prospective analysis. Am J Surg. 1985; 150: 90–96.

    Article  PubMed  CAS  Google Scholar 

  47. Lehtinen M, Laine S. Neinonen PK, et al. Serum C-reactive protein determination in acute pelvic inflammatory disease. Am J Obstet Gynecol. 1986; 154: 158–159.

    PubMed  CAS  Google Scholar 

  48. Dick JM, Kauer FM, Fleuren GJ, de Bruijin HW. Serum CA-125 levels in patients with provisional diagnosis of pelvic inflammatory disease: clinical and theoretical implications. Acta Obstet Et Gynecol Siandi. 1989; 68: 637–641.

    Article  Google Scholar 

  49. Kahn JG, Walker CK, Washington AE, Landers DV, Sweet RL. Diagnosing pelvic inflammatory disease: a comprehensive analysis and considerations for developing a new model. JAMA. 1991; 266: 2594–2604.

    Article  PubMed  CAS  Google Scholar 

  50. Centers for Disease Control. Pelvic inflammatory disease: policy guidelines for prevention and management. MMWR. 1991; 40 (RR-5): 1–25.

    Google Scholar 

  51. Brook I. Bacterial synergy in pelvic inflammatory disease. Arch Gynecol Obstet. 1987; 241: 133–143.

    Article  PubMed  CAS  Google Scholar 

  52. Westrom L. Pelvic inflammatory disease: bacteriology and sequelae. Contraception. 1987; 36: 111–128.

    Article  PubMed  CAS  Google Scholar 

  53. Paavonen J, Teisala K, Heinonen PK, et al. Microbiological and histopathological findings in acute pelvic inflammatory disease. Br J Obstet Gynecol. 1987; 94: 454–460.

    Article  CAS  Google Scholar 

  54. Centers for Disease Control. 1989 Sexually transmitted diseases treatment guidelines. MMWR. 1989:38(No. S-8): 31–33.

    Google Scholar 

  55. Centers for Disease Control. 1985 Sexually transmitted diseases treatment guidelines. MMWR. 1985; 34 (Suppl 4S): 19–21.

    Google Scholar 

  56. Obwegeser J, Kunz, J, Wust J, Schar G, Steiner R, Buchi W. Clinical efficacy of amoxycillin/ clavulanate in laparoscopically confirmed salpingitis. J Antimicrob Chemother. 1989; 24 (suppl B): 165–176.

    PubMed  Google Scholar 

  57. McGregor JA, Christiansen FB. Treatment of obstetric and gynecologic infections, with an emphasis on beta-lactamase-producing organisms. J Reprod Med. 1988; 33 (suppl 6): 595–597.

    Google Scholar 

  58. Crombleholme WR, Landers D, Ohm-Smith M, et al. Sulbactam/ampicillin versus metro- nidazole/gentamicin in the treatment of severe pelvic infections. Drugs. 1986; 3 (suppl 2): 11–13.

    Article  Google Scholar 

  59. Wolner-Hanssen P, Paavonen J, Kiviat N, Young M, Eschenbach DA, Holmes KK. Outpatient treatment of pelvic inflammatory disease with cefoxtin and doxycycline. Obstet Gynecol. 1988; 71: 595–600.

    PubMed  CAS  Google Scholar 

  60. Apuzzio JJ, Stankiewicz R, Jain S, Kaminski Z, Louria D. Comparison of parenteral ciprofloxacin with clindamycin-gentamicin in the treatment of pelvic infection. Am J Med. 1989; 87 (suppl 5A): 148S - 151S.

    Article  PubMed  CAS  Google Scholar 

  61. Crombleholme WR, Schachter J, Ohm-Smith M, Luft J, Whidden R, Sweet RL. Efficacy of single-agent therapy for the treatment of acute pelvic inflammatory disease with ciprofloxacin. Am J Med. 1989; 87 (suppl 5A): 142S - 147S.

    Article  PubMed  CAS  Google Scholar 

  62. Peterson HB, Walker CK, Kahn JG, Washington AE, Eschenback DA, Paro S. Pelvic inflammatory disease: treatment issues and options. JAMA. 1991; 266: 2605–2611.

    Article  PubMed  CAS  Google Scholar 

  63. Dodson MG, Faro S, Gentry LO. Treatment of acute pelvic inflammatory disease with aztreonam, a new monocyclic B-lactam antibiotic and clindamycin. Obstet Gynecol. 1986; 67: 657–662.

    Article  PubMed  CAS  Google Scholar 

  64. Pastorek JG II, Cole Cm, Aldridge KE, Cra- panzano JC. Aztreonam plus clindamycin as therapy for pelvic infections in women. Am J Med. 1985; 78 (suppl 2A): 47–50.

    Article  PubMed  Google Scholar 

  65. Jones RN. Review of the in vitro spectrum of activity of imipenem. Am J Med. 1985; 78 (supple 6A): 22–32.

    Article  PubMed  CAS  Google Scholar 

  66. Duff P. Obstetrics and Gynecology Clinics of North America: Antibiotic Use in Obstetrics and Gynecology. Philadelphia, Pa:WB Saunders; 1992:Vol 19, No. 3.

    Google Scholar 

  67. American College of Obstetricians and Gynecologists. Precis III: An Update in Obstetrics and Gynecology. Washington, DC: The American College of Obstetricians and Gynecologists; 1986: 17.

    Google Scholar 

  68. Landers DV, Sweet RL. Current trends in the diagnosis and treatment of tuboovarian abscess. Am J Obstet Gynecol. 1985; 151: 1098–1110.

    PubMed  CAS  Google Scholar 

  69. Sweet RL. Pelvic inflammatory disease: prevention and treatment. Modern Medicine. 1987; 55: 64–70.

    Google Scholar 

  70. Esenbach DA. Acute pelvic inflammatory disease. In: Schiarra JJ, Droegmeuller W, eds. Gynecology and Obstetrics, Rev ed. Philadelphia, Pa:JP Lippincott; 1990:(1)44:1–21

    Google Scholar 

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© 1993 Springer-Verlag New York, Inc.

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Sprang, M.L. (1993). Pelvic Inflammatory Disease. In: Knaus, J.V., Isaacs, J.H. (eds) Office Gynecology. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4340-3_7

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  • DOI: https://doi.org/10.1007/978-1-4612-4340-3_7

  • Publisher Name: Springer, New York, NY

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