Nipple Discharge

  • Antonio J. Bravo


The problem of nipple discharge and its clinical evaluation and management beginning in the office setting of the gynecologist, primary care physician, or surgeon are the focus of this chapter. Nipple discharge is fairly common, comprising 3% to 7% of chief complaints relating to the breast. This problem is very distressing to women because they feel that it may indicate the presence of a serious breast disease or cancer. To allay the patient’s fear, gentleness, concern, and reassurance must be expressed in this and all breast disease management. The assessment of nipple discharge aims to distinguish physiologic from pathologic discharge.


Pituitary Adenoma Breast Disease Nipple Discharge Serum Prolactin Level Intraductal Papilloma 
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  1. 1.
    Leis HP, Cammarata A, LaRaja RD. Nipple discharge: significance and treatment. Breast. 1985; 11: 6–12.Google Scholar
  2. 2.
    Urban JA, Egeli RA. Non-lactational nipple discharge. CA. 1978; 131–140.Google Scholar
  3. 3.
    Devitt J. Maanagement of nipple discharge by clinical findings. Am J Surg. 1985; 149: 789–792.PubMedCrossRefGoogle Scholar
  4. 4.
    Isaacs, JH. Diagnosis and treatment of benign lesions of the breast. In: Hindle WH, ed. Breast Disease for Gynecologists. New York: Appleton and Lange; 1990: 193–201.Google Scholar
  5. 5.
    Wertheimer MD. Diagnosis of malignant disease. In: Hindle WH, ed. Breast Disease for Gynecologists. New York: Appleton and Lange; 1990: 173–181.Google Scholar
  6. 6.
    Stehman FB. Infections and inflammations of the breast. In: Hindle WH, ed. Breast Disease for Gynecologists. New York: Appleton and Lange; 1990: 151–165.Google Scholar
  7. 7.
    Funderburk WW, Syphax B. Evaluation of nipple discharge in benign and malignant diseases. Cancer, 1969; 24: 1290–1296.PubMedCrossRefGoogle Scholar
  8. 8.
    Seltzer MH, Perloff LJ, Kelley RI, et al. The significance of age in patients with nipple discharge. Surg Gynecol Obstet. 1970; 131: 519–522.Google Scholar
  9. 9.
    Murad TM, Contesso G, Mouriesse H. Nipple discharge from the breast. Ann Surg. 1982; 259–264.Google Scholar
  10. 10.
    Chaudary MA, Millis RR, Davies GC, et al. Nipple discharge: the diagnostic value of testing for occult blood. Ann Surg. 1982; 196: 651–655.PubMedCrossRefGoogle Scholar
  11. 11.
    Speroff L, Glass RH, Kase NG. Amenorrhea. In: Speroff L, Glass RH, Kase NG, eds. Clinical Gynecologic Endocrinology and Infertility. 4th ed. Baltimorc, Md: Williams and Wilkins; 1989: 165–211.Google Scholar
  12. 12.
    Knight DC, Lowell, DPT. Aspiration of the breast and nipple discharge cytology. Surg Gynecol Obstet. 1986; 163: 415–420.PubMedGoogle Scholar
  13. 13.
    Lippman ME, Lichter AS, Danforth DRN. Evaluation of the patient with nipple discharge. In: Lippman ME, Lichter AS, Danforth DRN, eds. Diagnosis and Management of Breast Cancer. Philadelphia, Pa: WB Saunders; 1988: 7580.Google Scholar
  14. 14.
    Love SM, Schnitt SJ, Connolly JL, et al. Benign breast disorder. In: Harns JR, Henderson IC, Hellman et al, eds. Breast Diseases. Philadelphia, Pa: JB Lippincott; 1987: 15–53.Google Scholar
  15. 15.
    King EB, Goodson WH. Discharges and secretions of the nipple. In: Bland KI, Copeland EM, eds. The Breast: Comprehensive Management of Benign and Malignant Diseases. Philadelphia, Pa: WB Saunders; 1991: 46–67.Google Scholar

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© Springer-Verlag New York, Inc. 1993

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  • Antonio J. Bravo

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